Journal ArticleDOI
The pharmacokinetics of zinc from zinc gluconate: a comparison with zinc oxide in healthy men.
Martin Siepmann,S Spank,A Kluge,A Schappach,Wilhelm Kirch +4 more
- Vol. 43, Iss: 12, pp 562-565
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TLDR
Zinc absorption in humans could be improved by zinc complexation with gluconate by means of inductively coupled plasma-atomic emission spectroscopy.Abstract:
Objective: Zinc supplementation is beneficial in some clinical conditions such as age-related macula degeneration (AMD) It has been suggested that zinc absorption is influenced by the form in which zinc is ingested Therefore, the pharmacokinetics of zinc gluconate (organic) were compared with those of zinc oxide (inorganic) Methods: 12 healthy male subjects aged between 21 and 31 years (24 years median) orally received daily doses of 20 mg metal zinc as zinc gluconate and 174 mg metal zinc as zinc oxide under randomized crossover conditions for 14 days each with at least 14 days as a washout Zinc plasma concentrations were measured by means of inductively coupled plasma-atomic emission spectroscopy Results: C m a x was found 183% (103 - 263%) higher following multiple-dose administration of zinc gluconate as compared to zinc oxide (mean; 095% confidence interval of the relative differences between both treatment conditions; p < 005) AUC 0 - 2 4 h was noted 81% (19 - 143%) higher after zinc was given as zinc gluconate when compared to zinc oxide (p < 005) whereas t m a x did not differ between both treatment conditions Conclusions: Zinc absorption in humans could be improved by zinc complexation with gluconateread more
Citations
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Journal ArticleDOI
Zinc Absorption by Young Adults from Supplemental Zinc Citrate Is Comparable with That from Zinc Gluconate and Higher than from Zinc Oxide
TL;DR: It is concluded that zinc citrate, given as a supplement without food, is as well absorbed by healthy adults as zinc gluconate and may thus be a useful alternative for preventing zinc deficiency and treating diarrhea.
Journal ArticleDOI
A systematic review on zinc for the prevention and treatment of age-related macular degeneration.
TL;DR: Zinc treatment may be effective in preventing progression to advanced AMD and zinc supplementation alone may not be sufficient to produce clinically meaningful changes in visual acuity, based on the strength of AREDS.
Journal ArticleDOI
Zinc treatment prevents dysmenorrhea.
TL;DR: The side effect from the absence of all warning of pending menses due to zinc treatment was concern of possible pregnancy, and the United States RDA for zinc appears to be too low to optimize women's health and prevent menstrual cramping.
Journal ArticleDOI
Age-and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects : the Zenith study
Isabelle Hininger-Favier,M Andriollo-Sanchez,Josiane Arnaud,Nathalie Meunier,Séverine Bord,Ciaren Graham,Angela Polito,Giuseppe Maiani,Jacqueline M. O'Connor,Charles Coudray,Anne Marie Roussel +10 more
TL;DR: With respect to the key role of an optimal Zn status in successful ageing, Zn supplementation at 15 mg/d, when necessary, could be safely proposed regarding lipids and the risk of interaction with Fe and Cu.
Journal ArticleDOI
Trace Elements in Ovaries: Measurement and Physiology
TL;DR: X-ray absorption spectroscopy and x-ray fluorescence imaging are used to identify the in situ speciation and distribution of trace elements in tissues, using recent studies of bovine ovaries, where the distribution of Fe, Se, Zn, and bromine were determined.
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