The phase behavior of hydrated cholesterol.
TLDR
The observation of a smectic liquid crystalline phase for hydrated cholesterol correlates with its high surface activity and helps to explain its ability to exist in high concentrations in biological membranes.About:
This article is published in Journal of Lipid Research.The article was published on 1979-05-01 and is currently open access. It has received 217 citations till now. The article focuses on the topics: Water of crystallization & Thermotropic crystal.read more
Citations
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Maximum solubility of cholesterol in phosphatidylcholine and phosphatidylethanolamine bilayers.
TL;DR: It is found that artifactual demixing of cholesterol can occur during conventional sample preparation and that this demixed cholesterol may produce artifactual cholesterol crystals, and phospholipid/cholesterol suspensions which are prepared by conventional methods may manifest variable, falsely low cholesterol solubility limits.
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Role of gallbladder mucus hypersecretion in the evolution of cholesterol gallstones.
TL;DR: The results suggest that the increase in cholesterol content of bile in cholesterolfed prairie dogs stimulates gallbladder mucus hypersecretion, and that gallbladders mucus gel is a nucleating agent for biliary cholesterol.
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Intracellular cholesterol transport
TL;DR: This chapter provides an overview of the recent understanding of intracellular transport of cholesterol, aimed to create a link between the well characterized biophysical properties of cholesterol in model membranes and its behavior in living cells.
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Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry
TL;DR: Dietary cholesterol and fat were strongly and independently related to hormonal measures of insulin resistance and the efficiency of intestinal cholesterol absorption and the milligram amount of dietary cholesterol absorbed were not related to plasma cholesterol or LDL cholesterol in individuals consuming a low-cholesterol low-fat diet.
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Aspirin prevention of cholesterol gallstone formation in prairie dogs
TL;DR: Aspirin given to prairie dogs inhibited mucin hypersecretion and gel accumulation and prevented gallstone formation without influencing the cholesterol content of supersaturated bile, suggesting that gallbladder mucin is a nucleation matrix for cholesterol gallstones.
References
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Journal ArticleDOI
The fluid mosaic model of the structure of cell membranes.
S. J. Singer,Garth L. Nicolson +1 more
TL;DR: Results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglOBulin molecules are free to diffuse in the membrane.
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The physicochemical basis of cholesterol gallstone formation in man
William H. Admirand,Donald Small +1 more
TL;DR: The physical state of bile is suggested that the presence or absence of insoluble cholesterol is determined by the relative concentrations of biles salt, lecithin, and cholesterol, and the other biliary constituents do not appear to significantly effect the solubility of cholesterol in bile.
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The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man.
Martin C. Carey,Donald Small +1 more
TL;DR: The results demonstrate that cholesterol gallstone patients have supersaturated gallbladder and hepatic biles without exception, and the predominant driving force for cholesterol precipitation appears to be the absolute degree of cholesterol supersaturation.
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Phase equilibria and structure of dry and hydrated egg lecithin
TL;DR: The behavior of purified egg lecithin in water has been investigated in relation to the quantity of water present and the temperature and calculations suggest that the reason for this may be the presence of a "free water layer" when more than 16% water is present.
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Physical chemistry of the lipids of human atherosclerotic lesions. Demonstration of a lesion intermediate between fatty streaks and advanced plaques.
TL;DR: Identification of this group of intermediate lesions provides evidence that some fatty streaks may be precursors of advanced plaques and many chemical and physical features intermediate between ordinary fatty streaks and gruel plaques.
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Maximum solubility of cholesterol in phosphatidylcholine and phosphatidylethanolamine bilayers.
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