Journal ArticleDOI
Physical-Chemical Basis of Lipid Deposition in Atherosclerosis
Donald Small,G. Graham Shipley +1 more
About:
This article is published in Science.The article was published on 1974-07-19. It has received 283 citations till now. The article focuses on the topics: Lipid metabolism.read more
Citations
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Journal ArticleDOI
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
TL;DR: This research was supported by grants from the National Institutes of Health (HL20948) and the Perot Family Foundation.
Journal ArticleDOI
Cholesterol, inflammation and innate immunity
TL;DR: Therapeutic interventions such as increased production or infusion of high-density lipoproteins may sever the links between cholesterol accumulation and inflammation, and have beneficial effects in patients with metabolic diseases.
Journal ArticleDOI
Acyl-coenzyme a:cholesterol acyltransferase
TL;DR: This chapter summarizes the current knowledge on ACAT-related research in two areas: 1) ACAT genes and proteins and 2) AC AT enzymes as drug targets for atherosclerosis and for Alzheimer's disease.
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Plasma high-density lipoproteins.
Alan R. Tall,Donald Small +1 more
TL;DR: All the recent excitement about highdensity lipoproteins (HDL) is due to the strong inverse relation between plasma levels of HDL and mortality from cardiovascular disease.
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Carotid Atherosclerotic Plaque: Noninvasive MR Characterization and Identification of Vulnerable Lesions
TL;DR: Improved imaging techniques are needed to enable reliable identification of high-risk plaques that lead to cerebrovascular events and the use of carotid MR to evaluate plaque morphology and composition.
References
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Journal ArticleDOI
Fat Transport in Lipoproteins — An Integrated Approach to Mechanisms and Disorders
TL;DR: The Type II hyperlipoproteinemia as mentioned in this paper is defined as an increase in the concentration of lipoproteins that have discrete β-mobility, and is defined by the Type II lipoprotein pattern.
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Structure and polymorphism of the hydrocarbon chains of lipids: a study of lecithin-water phases.
TL;DR: The structure of lecithin-water phases observed below the melting temperature of the hydrocarbon chains, with special emphasis on the conformation of the chains, is described in this paper.
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The physicochemical basis of cholesterol gallstone formation in man
William H. Admirand,Donald Small +1 more
TL;DR: The physical state of bile is suggested that the presence or absence of insoluble cholesterol is determined by the relative concentrations of biles salt, lecithin, and cholesterol, and the other biliary constituents do not appear to significantly effect the solubility of cholesterol in bile.
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Physical studies of phospholipids. VI. Thermotropic and lyotropic mesomorphism of some 1,2-diacyl-phosphatidylcholines (lecithins)
TL;DR: The thermotropic and lyotropic mesomorphism of saturated 1,2-diacyl-L-phosphatidylcholines (lecithins) has been studied by light microscopy, differential thermal analysis, X-ray diffraction, infrared and nuclear magnetic resonance spectroscopy.
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Studies on lecithin-cholesterol-water interactions by differential scanning calorimetry and X-ray diffraction
TL;DR: The cholesterol controls the fluidity of the hydrocarbon chains of the phospholipid by disruption of the crystalline chain lattice of the gel phase, and by inhibiting the flexing of chains in the dispersed liquid crystalline phase.