The Possibility of TBC1D21 as a Candidate Gene for Teat Numbers in Pigs
Shil Jin,Joon-Hee Lee,K. Kang,Chae-Kyoung Yoo,Byeongwoo Kim,Hee-Bok Park,Hyun-Tae Lim,I. C. Cho,Dyah Maharani,Jun Heon Lee +9 more
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TLDR
Based on a quantitative traits locus (QTL) study using a F2 intercross between Landrace and Korean native pigs, a significant QTL affecting teat numbers in SSC7 was identified and the strong positional candidate gene, TBC1D21, was selected due to its biological function for epithelial mesenchymal cell development.Abstract:
Based on a quantitative traits locus (QTL) study using a F2 intercross between Landrace and Korean native pigs, a significant QTL affecting teat numbers in SSC7 was identified. The strong positional candidate gene, TBC1D21, was selected due to its biological function for epithelial mesenchymal cell development. Sequence analysis revealed six single nucleotide polymorphisms (SNPs) in the TBC1D21 gene. Among these, two SNP markers, one silent mutation (SNP01) for g.13,050A>G and one missense mutation (SNP04) for c.829A>T (S277C), were genotyped and they showed significant associations with teat number traits (p value = 6.38E-05 for SNP01 and p value = 1.06E-07 for SNP04 with total teat numbers). Further functional validation of these SNPs could give valuable information for understanding the teat number variation in pigs. (Key Words: QTL, SNP, SSC7, TBC1D21, Teat Number, Pig)read more
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Genotyping by sequencing reveals a new locus for pig teat number
TL;DR: Genotyping-by-sequencing and a general liner model was used to carry out genome-wide analysis of sow total teat number in an Erhualian population and inferred the presence of a gene or lincRNA that could affect teatNumber by regulating other genes and ultimately affecting the mammogenesis of pigs.
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A new method for detection of single nucleotide polymorphism in a female reproduction-associated gene, tmigd1, of Anas platyrhynchos using a strip biosensor with gold nanoparticles.
TL;DR: A new system for detection of single nucleotide polymorphism in a female reproduction-associated gene, tmigd1, of Anas platyrhynchos, is developed using the strip biosensor, and the optimized parameters for the concentration of Mg2+ in the PEXT reaction and the amount of streptavidin used on membranes for signal specificity are identified.
References
More filters
Journal ArticleDOI
Haploview: analysis and visualization of LD and haplotype maps
TL;DR: Haploview is a software package that provides computation of linkage disequilibrium statistics and population haplotype patterns from primary genotype data in a visually appealing and interactive interface.
Journal ArticleDOI
The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models.
TL;DR: The results of these investigations were sufficient to show that even for relatively simple cases (two loci, simple symmetrical selective values) linkage might have profound effects on the course of natural selection and, pari passu, natural selection may have major effect on the distribution of coupling and repulsion linkage in a population.
Journal ArticleDOI
Identification of quantitative trait loci affecting reproduction in pigs.
J. P. Cassady,Rodger K. Johnson,Daniel Pomp,Gary A. Rohrer,L. D. Van Vleck,E. K. Spiegel,K. M. Gilson +6 more
TL;DR: Ovulation rate and age at puberty are laborious to measure, and thus marker-assisted selection may provide a practical and efficient method of selection.
Journal ArticleDOI
Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways
Evelyn Fuchs,Alexander K. Haas,Robert A. Spooner,Shin-ichiro Yoshimura,Shin-ichiro Yoshimura,Janet M. Lord,Francis A. Barr +6 more
TL;DR: The results suggest that Shiga toxin trafficking to the Golgi is a multistep process controlled by several Rab GAPs and their target Rabs and that this process is discrete from ligand-induced EGF receptor trafficking.
Journal ArticleDOI
Quantitative trait loci (QTL) analysis in a Meishan x Göttingen cross population.
Y Wada,T Akita,Takashi Awata,T Furukawa,N. Sugai,Y Inage,K Ishii,Y Ito,Eiji Kobayashi,H. Kusumoto,Toshimi Matsumoto,Satoshi Mikawa,M Miyake,A Murase,S Shimanuki,T Sugiyama,Y. Uchida,S Yanai,H. Yasue +18 more
TL;DR: In order to locate the genetic regions in the swine genome that are responsible for economically important traits, a resource population has been constructed by mating two female Meishan pigs with a male Göttingen miniature pig.