Open AccessJournal Article
The prognostic value of blood glucose level on admission in non-diabetic patients with acute myocardial infarction.
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TLDR
The admittance blood glucose level represents a useful and available marker for the initial stratification of risks in patients with acute myocardial infarction, even in those undiagnosed with diabetes mellitus.Abstract:
UNLABELLED The diabetic patients represent a population with a high risk of morbidity and mortality because of vascular complications. Out of them, all the patients with acute ST-elevation myocardial infarction have a more reserved prognostic than those without diabetes mellitus. Moreover, the patients with impaired glucose tolerance have a more severe evolution in case of a myocardial infarction. AIM We wondered about the progress of patients with myocardial infarction and high blood glucose levels in admittance who had not been previously diagnosed with diabetes mellitus. MATERIALS AND METHODS We took 128 patients (who did not have diabetes) with acute ST-elevation myocardial infarction and divided them into three groups, according to the blood glucose level in admittance ( 200 mg/dL); we also analyzed a group of diabetics with acute myocardial infarction who were admitted in the same period in our clinic. We made a prospective analysis over a period of 30 days. We evaluated the mortality at 30 days (as primary objective), as well as the extent of the infarction and the change of the left ventricle systolic function (secondary objectives). RESULTS Both mortality and the mass of myocardial necrosis grew relative to the blood glucose level in admittance; instead, the ejection fraction varied inversely to the initial blood glucose level. CONCLUSION The admittance blood glucose level represents a useful and available marker for the initial stratification of risks in patients with acute myocardial infarction, even in those undiagnosed with diabetes mellitus.read more
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Journal ArticleDOI
Diabetes and cardiovascular disease : A statement for healthcare professionals from the American heart association
Scott M. Grundy,Ivor J. Benjamin,Gregory L. Burke,Alan Chait,Robert H. Eckel,Barbara V. Howard,William E. Mitch,Sidney C. Smith,James R. Sowers +8 more
TL;DR: The most prevalent form of diabetes mellitus is type 2 diabetes as discussed by the authors, which typically makes its appearance later in life and is associated with other cardiovascular risk factors: dyslipidemia, hypertension, and prothrombotic factors.
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Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): Effects on mortality at 1 year
Klas Malmberg,Lars Rydén,Suad Efendic,Johan Herlitz,Peter Nicol,Anders Waldenström,Hans Wedel,Lennart Welin +7 more
TL;DR: Insulin-glucose infusion followed by a multidose insulin regimen improved long-term prognosis in diabetic patients with acute myocardial infarction.
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Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: a prospective study
Anna Norhammar,Åke Tenerz,Göran E. Nilsson,Anders Hamsten,Suad Efendic,Lars Rydén,Klas Malmberg +6 more
TL;DR: The results suggest that fasting and postchallenge hyperglycaemia in the early phase of an acute myocardial infarction could be used as early markers of high-risk individuals.
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Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity
Karl-Johan Malmberg,Lars Rydén,Hans Wedel,Kåre I. Birkeland,A Bootsma,Kenneth Dickstein,S. Efendic,Miles Fisher,Anders Hamsten,Johan Herlitz,Per Hildebrandt,K MacLeod,Markku Laakso,C Torp-Pedersen,Anders Waldenström +14 more
TL;DR: Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2) : effects on mortality and morbidity.
Journal ArticleDOI
Glycometabolic State at Admission: Important Risk Marker of Mortality in Conventionally Treated Patients With Diabetes Mellitus and Acute Myocardial Infarction Long-Term Results From the Diabetes and Insulin-Glucose Infusion in Acute Myocardial Infarction (DIGAMI) Study
TL;DR: Mortality in diabetic patients with AMI is predicted by age, previous heart failure, and severity of the glycometabolic state at admission but not by conventional risk factors or sex.