Journal ArticleDOI
The role of CRF in the release of ACTH by opiate agonists and antagonists in rats
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It is concluded that endogenous opioids tonically inhibit the release of CRF, kappa-agonists stimulate therelease ofCRF, and mu-agonists release ACTH by acting additionally through CRF-independent mechanisms.About:
This article is published in Brain Research.The article was published on 1987-09-22. It has received 93 citations till now. The article focuses on the topics: Endogenous opioid & ACTH receptor.read more
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The Role of Corticotropin-Releasing Factor in Drug Addiction
TL;DR: The goal of this article is to summarize available data examining the physiological significance of brain corticotropin-releasing factor systems in mediating the behavioral and physiological effects of several classes of abused drugs, including opioid and psychostimulant drugs, alcohol and sedative hypnotics, nicotine, and cannabinoids.
Journal ArticleDOI
Dynorphin, stress, and depression
TL;DR: This review summarizes current data on how KOR systems contribute to the acute, delayed, and cumulative molecular and behavioral effects of stress and focuses on behavioral paradigms that provide insight on interactions between stress and KOR function within each of these temporal categories.
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The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse
Sunmee Wee,George F. Koob +1 more
TL;DR: κ receptor agonists antagonize the reinforcing/rewarding effects of drugs possibly through punishing/aversive-like effects and reinstate drug seeking through stress- like effects and evidence suggests that abused drugs activate the κ opioid system, which may play a key role in motivational aspects of dependence.
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Role of kappa-opioid receptors in stress and anxiety-related behavior.
TL;DR: Collectively, available data suggest that KOR disruption produces anti-stress effects and under some conditions can prevent the development of stress-induced adaptations, suggesting KOR antagonists may have unique potential as therapeutic agents for the treatment and even prevention of Stress-related psychiatric illness.
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Journal ArticleDOI
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
TL;DR: A peptide with high potency and intrinsic activity for stimulating the secretion of corticotropin-like and β-endorphinlike immunoactivities by cultured anterior pituitary cells has been purified in this paper.
Journal ArticleDOI
Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin.
TL;DR: It is reported here that the new CRF is more potent than vasopressin in releasing ACTH and potentiation of CRF activity with steep dose–response characteristics was observed, suggesting that thenew CRF does not account for all the non-vasopressIn portion of the CRF complex.
Book
Methods of hormone radioimmunoassay.
TL;DR: This ebooks is under topic such as a radioimmunoassay method for human pituitary luteinizing methods inRadioimmunOassay, toxicology, and springer, and a rapid radioIMmunoASSay method of (39161) ultrafiltration method for direct radioim Muncoassay measurement new solid phases for estimation of hormones by agreement between electrochemiluminescence and raciloimmunosynthesis.
Journal ArticleDOI
Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin
Catherine Rivier,Wylie Vale +1 more
TL;DR: It is reported here that pretreatment with a vasopressin antagonist decreases the plasma ACTH levels of ether-stressed rats in later (10–20 min), but not earlier (0–10 min), phases of ether stress, which supports a role of CRF, catecholamines and vasopressing factor in mediating ACTH release by ether stress.
Journal ArticleDOI
The corticotropin-releasing factor stimulation test. An aid in the evaluation of patients with Cushing's syndrome.
George P. Chrousos,Heinrich M. Schulte,Edward H. Oldfield,Phillip W. Gold,Gordon B. Cutler,D. L. Loriaux +5 more
TL;DR: Investigation of the effect of exogenous corticotropin-releasing factor on plasma levels of ACTH and cortisol in patients with ACTH-secreting pituitary adenomas and other forms of Cushing's syndrome concludes that stimulation of the pituitaries-adrenal axis with corticotropic factor may be useful in differentiating pituitsary from ectopic causes of Cushed's syndrome.