Open AccessJournal Article
The role of intermedial filament nestin in malignant melanoma progression
TLDR
Significant increase in nestin expression in melanoma groups, especially in nodular melanomas, where nestin was localized mainly in the peripheral, invasive areas of the tumor mass.Abstract:
UNLABELLED Nestin is one of intermedial filaments exprimed in proliferating progenitor cells of the CNS and PNS (central and peripheral nervous system). Postnatal reexpression of the protein occures mainly in CNS tumors and correlates with a high grade of malignancy. The aim of our study is assessment of the nestin expression in benign and malignant skin melanocytic lesions with respect to presume a prognostic role of this protein. We examined 127 bioptic specimens, including 42 nodular melanomas (NM), 32 superficial spreading melanomas (SSM), 10 dysplastic nevi and 43 common intradermal or dermoepidermal nevi. We proved significant increase in nestin expression in melanoma groups, especially in nodular melanomas, where nestin was localized mainly in the peripheral, invasive areas of the tumor mass. CONCLUSION Detection of nestin expression might be used as an additional melanocytic tumour marker.read more
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Biomarkers: the useful and the not so useful--an assessment of molecular prognostic markers for cutaneous melanoma.
TL;DR: 101 additional proteins that stratify melanoma are identified, organized according to the Hanahan and Weinberg functional capabilities of cancer.
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Identification of CD133+/nestin+ putative cancer stem cells in non-small cell lung cancer.
Maria Janikova,Jozef Skarda,Marta Dziechciarkova,Lenka Radová,Jana Chmelová,Veronika Krejci,Eva Sedlakova,Jana Zapletalová,Katerina Langova,Jiri Klein,Ivona Grygárková,Vitezslav Kolek +11 more
TL;DR: CD133(+)/nestin(+) cells as novel potential markers of lung cancer CSCs are identified via detection of the expression of stem cell markers - CD133 and nestin.
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Novel biomarkers and therapeutic targets for optimizing the therapeutic management of melanomas.
TL;DR: Recent advances in the melanoma research have led to the identification of different gene products that are often implicated in the malignant transformation of melanocytic cells into melanoma cells, including melanoma stem/progenitor cells, during melanoma initiation and progression to locally advanced and metastatic disease states.
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Long-Term Inhibition of Notch in A-375 Melanoma Cells Enhances Tumor Growth Through the Enhancement of AXIN1, CSNK2A3, and CEBPA2 as Intermediate Genes in Wnt and Notch Pathways.
Faezeh Keyghobadi,Faezeh Keyghobadi,Maryam Mehdipour,Vahab Nekoukar,Javad Firouzi,Abolfazl Kheimeh,Fatemeh Nobakht Lahrood,Vajihe Azimian Zavareh,Masoumeh Azimi,Mahsa Mohammadi,Niloofar Sodeifi,Marzieh Ebrahimi +11 more
TL;DR: The data supported that the long-term and not short-term inhibition of Notch by DAPT may enhance tumor growth and motility through up-regulation of AXIN1, CSNK2A3, and CEBPA2 genes in B-raf mutated A375 cells.
Journal Article
[Effect of lentivirus-mediated nestin gene silencing on metastatic potential of human melanoma cell line UACC903 in vitro].
TL;DR: Lentivirus-mediated nestin RNAi can specifically inhibit nestin expression to cause decreased cell migration and invasiveness of human melanoma cell line UACC903.
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