The role of phosphate in the secretion of parathyroid hormone in man
TLDR
The experiments show that oral phosphorus administration initiates a calcium-mediated control system for PTH secretion and that this system operates very sensitively in man.Abstract:
In man, oral administration of 1 g of phosphorus resulted in a 60-125% increase in serum immunoassayable parathyroid hormone (PTH) concentration. Peak PTH levels were attained in 1 hr, and PTH returned to base line levels in 2 hr. This increase in PTH appeared to be initiated by a very small decrease of total and ionized calcium and was abolished by a calcium infusion. There was no correlation between serum phosphorus and PTH. The experiments show that oral phosphorus administration initiates a calcium-mediated control system for PTH secretion and that this system operates very sensitively in man.read more
Citations
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Journal ArticleDOI
Phosphorus restriction prevents parathyroid gland growth. High phosphorus directly stimulates PTH secretion in vitro.
Eduardo Slatopolsky,Jane Finch,Masashi Denda,Cindy Ritter,M. Zhong,Adriana Dusso,Paul N. MacDonald,Alex J. Brown +7 more
TL;DR: In vivo and in vitro results demonstrate a direct action of P on PTG function that is independent of ICa and 1,25-(OH)2D3, and posttranscriptional, affecting PTH at a translational or posttranslational step.
Journal ArticleDOI
On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog
Eduardo Slatopolsky,Sali Caglar,J. P. Pennell,Dennis D. Taggart,Janet M. Canterbury,Eric Reiss,Neal S. Bricker +6 more
TL;DR: The data suggest that the control system regulating phosphate excretion contributes importantly to the pathogenesis of secondary hyperparathyroidism in advancing renal insufficiency.
Journal ArticleDOI
Evidence for Secondary Hyperparathyroidism in Idiopathic Hypercalciuria
TL;DR: A reasonable working hypothesis is that idiopathic hypercalciuria is often due to a primary renal defect of calcium handling that leads, by unknown pathways, to secondary hyperparathyroidism.
Journal ArticleDOI
The Importance of Phosphate in Regulating Plasma 1,25-(OH)2-Vitamin D Levels in Humans: Studies in Healthy Subjects, in Calcium-Stone Formers and in Patients with Primary Hyperparathyroidism*
TL;DR: It is concluded that reductions in serum PO4 concentrations, either directly or indirectly, stimulate renal synthesis of 1,25-(OH)2-D in humans.
References
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TL;DR: Findings suggest that parathyroid hormone in human plasma is imbalanced and the apparent disappearance of par Kathyroid hormone was more rapid when measured in antiserum C329 than in antisersum 273 and in both antisera was slower in patients with renal insufficiency than in patientsWith 1° hyperparathyroidism.
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Parathyroid Hormone in Plasma in Adenomatous Hyperparathyroidism, Uremia, and Bronchogenic Carcinoma
TL;DR: The concentration of parathyroid hormone (measured by radioimmunoassay) in plasma of patients with severe chronic uremia is frequently much higher than it is in the majority of cases having adenomatous hyperparathyroidism.
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Regulation of parathyroid hormone secretion: proportional control by calcium, lack of effect of phosphate
TL;DR: Analyses for parathyroid hormone and calcium in peripheral plasma showed a simple linear inverse function of hormone concentration vs. plasma calcium, which led to the conclusion that calcium regulates hormonal secretion predominantly through a proportional control mechanism.