The Role of Renin in the Exaggerated Natriuresis of Hypertension
TLDR
The enhanced capacity of the renin-unresponsive hypertensive subjects to excrete a salt load suggests either a functionally significant degree of extracellular fluid volume expansion or a direct role for renin in the natriuresis accompanying volume expansion.Abstract:
Hypertensive patients were classified according to their plasma renin response when challenged by the potent diuretics, ethacrynic acid (50 mg IV), or furosemide (40 mg IV), into renin-unresponsive and renin-responsive groups In the latter plasma renin activity rose by at least 05 ng of angiotensin/ml/hr after the diuretic The response to volume expansion with 2 L of isotonic saline infused over 60 min was then studied Peak rate of sodium excretion after saline loading was 994±186 µEq/min in the renin-unresponsive group and peak urine flow was 119 ± 21 ml/min In the renin-responsive hypertensives peak sodium excretion was 448 ± 149 µEq/min and peak urine flow was 54 ± 15 ml/min Both the sodium excretion and urine flow responses were significantly higher (P < 005) in the renin-unresponsive group The degree of saline-induced diuresis and natriuresis was not related to the preexisting level of aldosterone production Plasma renin changed little in either group during saline infusion but tended toread more
Citations
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References
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Journal ArticleDOI
Metabolic Studies on Hypertensive Patients with Suppressed Plasma Renin Activity Not Due to Hyperaldosteronism
Oscar M. Helmer,Walter E. Judson +1 more
TL;DR: In this article, metabolic data obtained during sodium depletion from 13 hypertensive patients (HT) with low renin activity (PRA) were compared with data from 15 normotensive subjects and three patients with renovascular hypertension (RHT).
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Plasma Renin Activity and Aldosterone Secretion in Hypertensive Patients During High and Low Sodium Intake and Administration of Diuretic
TL;DR: Plasma renin activity (PRA) and aldosterone secretion or excretion rates have been measured in 35 hypertensive patients and PRA was found to be above the normal range in malignant hypertension and in some patients with renovascular and essential hypertension.
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Effect of an Intravenous Sodium Chloride Load on Renal Hemodynamics and Electrolyte Excretion in Essential Hypertension
TL;DR: An abnormality was characterized by increased renal tubular rejection of sodium, chloride and water in patients with progressively more severe grades of hypertension and of increased renal vascular resistance.
Journal Article
The meaning of aldosteronism in hypertensive disease.
TL;DR: Primary aldosteronism is an uncommon cause of hypertension, but in this group of parents adrenal surgery may be curative, and in the more severe forms of renovascular hypertension manifest hypersecretion.
Journal ArticleDOI
Nature of renal escape from the sodium-retaining effect of aldosterone in primary aldosteronism and in normal subjects.
TL;DR: The maximum mean rate of sodium excretion in response to the intravenous saline load (UNsV) in the control subjects was decreased below base line at the end of the first day of administration of aldosterone, but was significantly increased above base-line values after escape had developed and while ald testosterone was still being given.