Effects of alpha-human atrial natriuretic peptide in essential hypertension.
Arthur Mark Richards,M G Nicholls,Eric A. Espiner,Hamid Ikram,Yandle Tg,S.L. Joyce,Cullens M +6 more
TLDR
Compared with normotensive volunteers studied previously under the same conditions, the hypertensive subjects had a greater response in urine volume and sodium, calcium, and magnesium excretion but a less sustained fall in arterial pressure.Abstract:
Because there is little published information on the effects of atrial peptides in hypertensive humans, 100 micrograms of alpha-human atrial natriuretic peptide was injected intravenously into six patients with essential hypertension in a double-blind, placebo-controlled study under standardized conditions of body posture and dietary sodium and potassium intake. The peptide increased urine sodium excretion sixfold in the first 30 minutes. Smaller increments occurred in urine volume and in calcium, magnesium, and phosphorus excretion; the rise in urine potassium concentration was not statistically significant. Most of these indices returned to time-matched placebo values within 1 hour, but urine sodium excretion remained high for 2 1/2 hours. Arterial pressure fell within 2 minutes of alpha-human atrial natriuretic peptide injection, then returned to matching placebo levels by 10 minutes. Conversely, heart rate increased rapidly and remained elevated for 3 hours. The peptide induced a prompt, brief rise in plasma norepinephrine concentration and a more sustained fall in epinephrine and aldosterone levels, but it did not affect plasma renin activity or cortisol concentration. Compared with normotensive volunteers studied previously under the same conditions, the hypertensive subjects had a greater response in urine volume and sodium, calcium, and magnesium excretion but a less sustained fall in arterial pressure.read more
Citations
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Atriopeptin: a cardiac hormone intimately involved in fluid, electrolyte, and blood-pressure homeostasis.
TL;DR: This review focuses on the recent discovery of atriopeptin, a peptide hormone that is intimately involved in the regulation of renal and cardiovascular homeostasis.
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GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
Minsuk Kim,Mathew J. Platt,Tadao Shibasaki,Susan E. Quaggin,Peter H. Backx,Susumu Seino,Jeremy A. Simpson,Daniel J. Drucker +7 more
TL;DR: It is demonstrated that cardiac Glp1r expression is localized to cardiac atria and that GLP-1R activation promotes the secretion of atrial natriuretic peptide (ANP) and a reduction of blood pressure, defining a gut-heart GLP–1R–dependent and ANP–dependent axis that regulates blood pressure.
Journal ArticleDOI
Clinical application of atrial natriuretic polypeptide in patients with congestive heart failure: beneficial effects on left ventricular function.
Y. Saito,Koichi Nakao,Kazunobu Nishimura,Akira Sugawara,Ken Okumura,Kenji Obata,Ryuji Sonoda,Toshihiko Ban,Hirofumi Yasue,Hiroo Imura +9 more
TL;DR: The findings indicate that the ANP infusion improves left ventricular function in patients with CHF, and suggest that this improvement results mainly from the vasodilating activity of ANP.
Journal ArticleDOI
Radioimmunoassay and characterization of atrial natriuretic peptide in human plasma.
TL;DR: Plasma immunoreactive ANP is responsive to sodium loading in normal man and is elevated in patients with hypervolemic disorders, indicating that the heart secretes alpha hANP or a closely similar peptide which is also present in peripheral venous plasma.
References
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Journal ArticleDOI
Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine.
TL;DR: Modification of the original single isotope radioenzymatic assay of Passon and Peuler permits the direct and simultaneous analysis of norepinephrine, epinephrine and dopamine in plasma samples of 50 μl or less.
Journal ArticleDOI
Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide (α-hANP)
Kenji Kangawa,Hisayuki Matsuo +1 more
TL;DR: A survey for natriuretic factors in human atrial extract was performed by using in vitro assay for the relaxant effect on the contractility of chick rectum.
Journal ArticleDOI
Renal, haemodynamic, and hormonal effects of human alpha atrial natriuretic peptide in healthy volunteers
TL;DR: There were no significant changes in plasma renin activity, aldosterone, antidiuretic hormone, or noradrenaline when compared with placebo when the effects of atrial natriuretic peptide were investigated in healthy male volunteers taking a constant diet.
Journal ArticleDOI
Specific receptor-mediated inhibition by synthetic atrial natriuretic factor of hormone-stimulated steroidogenesis in cultured bovine adrenal cells.
TL;DR: The results demonstrate that part of the natriuretic effect of this new factor might be due to inhibition of adrenal steroidogenesis by action through a distinct receptor.
Journal ArticleDOI
Actions of synthetic atrial natriuretic factor on bovine adrenal glomerulosa
Theodore L. Goodfriend,Theodore L. Goodfriend,Mary E. Elliott,Mary E. Elliott,Steven A. Atlas,Steven A. Atlas +5 more
TL;DR: Synthetic atrial natriuretic factor inhibited aldosterone production by suspensions of bovine adrenal glomerulosa cells and had no effect on binding of AII to receptors, on the stimulation by A II of phospholipid turnover, or on the alteration by AII of calcium fluxes.
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