The synovial microvascular derangement in rheumatoid arthritis and osteoarthritis.
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This article is published in Acta Orthopaedica Scandinavica.The article was published on 1969-01-01 and is currently open access. It has received 43 citations till now. The article focuses on the topics: Rheumatoid arthritis & Osteoarthritis.read more
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The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity.
TL;DR: This study represents the first therapeutic effect of an angiostatic steroid in an animal model of neovascular retinopathy and holds therapeutic potential for a number of human ocular conditions in which angiogenesis plays a critical pathologic role.
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Suramin prevents neovascularisation and tumour growth through blocking of basic fibroblast growth factor activity.
TL;DR: In an in vivo model of tumour-induced angiogenesis using the murine M5076 reticulosarcoma, suramin was able to reduce tumour growth and tumour inducedAngiogenesis, and exogenous administration of bFGF countered suramin effects.
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Mechanism of action of angiostatic steroids: Suppression of plasminogen activator activity via stimulation of plasminogen activator inhibitor synthesis
TL;DR: In this article, the authors showed that the fibrinolytic response of endothelial cells to the angiogenic protein, basic fibroblast growth factor [bFGF], was abrogated by the presence of 10−6 M MPA.
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Hypoxia and inflammatory synovitis: observations and speculation.
TL;DR: It is now clear that an understanding of the physiological and pathological effects of joint hypoxia is of great importance to both clinical and research rheumatology, and explanations for the phenomenon are offered.
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Intra-articular targeting of nanomaterials for the treatment of osteoarthritis.
TL;DR: This article comprehensively reviews the advances in nano-scale delivery vehicles designed to overcome the delivery barriers in the joint, and is the first review to analyze active and passive targeting strategies systematically for different target sites while also delineating between tissue homing and whole joint retention.
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The Arteritis of Rheumatoid Arthritis
TL;DR: The occurrence of vascular lesions in rheumatoid arthritis has been recognized for some time, but interest in them has been of a sporadic nature until recently.