Journal ArticleDOI
The Synthesis of Aryl-D-glucopyranosiduronic Acids1
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This article is published in Journal of the American Chemical Society.The article was published on 1955-06-01. It has received 305 citations till now. The article focuses on the topics: Aryl.read more
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Ethyl glucuronide: an unusual ethanol metabolite in humans. Synthesis, analytical data, and determination in serum and urine
TL;DR: Ethyl glucuronide (ethyl beta-D-6-glucosiduronic acid), a minor ethanol metabolite in serum or urine, was determined by gas chromatography-mass spectrometry by synthesizing by the reaction of acetobromo-glUCosiduonic acid with ethanol.
Journal ArticleDOI
A Gadolinium Chelate for Detection of β-Glucuronidase: A Self-Immolative Approach
TL;DR: This work has synthesized in nine steps a Gd(III) agent 1 that is activated by the oncologically significant β-glucuronidase, and investigated the properties of these agents using novel in vitro assays.
Journal ArticleDOI
Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activity.
Lai-Xi Wang,Alonso Heredia,Haijing Song,Zhaojun Zhang,Biao Yu,Charles E. L. B. Davis,Robert R. Redfield +6 more
TL;DR: It is found that resveratrol was metabolized in humans into two metabolites, which were characterized as resver atrol-3-O- and 4'-O-glucuronides, which have implications for future development of resverAtrol and/or its derivatives as a chemotherapeutic agent.
Journal ArticleDOI
Design and synthesis of water-soluble glucuronide derivatives of camptothecin for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT).
TL;DR: Compounds 4 and 12 may be useful for prodrug monotherapy of tumors that accumulate extracellular lysosomal beta-glucuronidase as well as for antibody-directed enzyme prodrug therapy (ADEPT) of cancer.
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Steroid conjugates. VI. An improved Koenigs-Knorr synthesis of aryl glucuronides using cadmium carbonate, a new and effective catalyst.
Conrow Rb,Bernstein S +1 more