The Treatment of Hyperhomocysteinemia
Bradley A. Maron,Joseph Loscalzo +1 more
TLDR
The unique biochemical profile of homocysteine is characterized by chemical reactivity supporting a wide range of molecular effects and by a tendency to promote oxidant stress-induced cellular toxicity, including the primary prevention of atherothrombotic disease in individuals at low or intermediate risk, or those with severe hyperhomocysteinemia.Abstract:
The unique biochemical profile of homocysteine is characterized by chemical reactivity supporting a wide range of molecular effects and by a tendency to promote oxidant stress-induced cellular toxicity. Numerous epidemiological reports have established hyperhomocysteinemia as an independent risk factor for cardiovascular disease, cerebrovascular disease, dementia-type disorders, and osteoporosis-associated fractures. Although combined folic acid and B-vitamin therapy substantially reduces homocysteine levels, results from randomized placebo-controlled clinical trials testing the effect of vitamin therapy on outcome in these diseases have generally fallen short of expectations. These results have led some to abandon homocysteine monitoring in the management of patients with cardiovascular or cognitive disorders. These trials, however, have generally included patients with only mildly elevated homocysteine levels and have not addressed several clinical scenarios in which homocysteine reduction may be effective, including the primary prevention of atherothrombotic disease in individuals at low or intermediate risk, or those with severe hyperhomocysteinemia.read more
Citations
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Homocysteine‐lowering interventions for preventing cardiovascular events
TL;DR: Whether homocysteine-lowering interventions, provided to patients with and without pre-existing cardiovascular disease are effective in preventing cardiovascular events, as well as reducing all-cause mortality, and to evaluate their safety is evaluated.
Journal ArticleDOI
The metabolism and significance of homocysteine in nutrition and health
Avinash Kumar,Henry A. Palfrey,Rashmi Pathak,Philip J. Kadowitz,Thomas W. Gettys,Subramanyam N. Murthy +5 more
TL;DR: Despite associations between increased levels of Hcy with several pathologies being well documented, whether it is a causative factor, or an effect remains inconclusive, the present review though not exhaustive, is focused on several important aspects of H Cy metabolism and their relevance to health.
Journal ArticleDOI
The Therapeutic Potential of Hydrogen Sulfide: Separating Hype from Hope
TL;DR: The concentration of H(2)S in tissues and blood, as well as the intrinsic factors that affect these levels, has not been resolved, and it is imperative to address these points to distinguish between the physiological, pharmacological, and toxicological effects of this molecule.
Journal ArticleDOI
Schiff bases in medicinal chemistry: a patent review (2010-2015).
TL;DR: This review aims to provide a comprehensive overview of the various patented therapeutic applications of Schiff bases and their metal complexes from 2010 to 2015 and has been used to coordinate almost all d-block metals as well as lanthanides.
Journal ArticleDOI
Therapies for Prevention and Treatment of Alzheimer’s Disease
TL;DR: Strategies for prevention of AD through nonpharmacological treatments are associated with lifestyle interventions such as exercise, mental challenges, and socialization as well as caloric restriction and a healthy diet.
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