Journal ArticleDOI
The use of confidence or fiducial limits illustrated in the case of the binomial
C. J. Clopper,E. S. Pearson +1 more
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This article is published in Biometrika.The article was published on 1934-12-01. It has received 4095 citations till now. The article focuses on the topics: Binomial proportion confidence interval & Binomial (polynomial).read more
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Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs
Varun Gulshan,Lily Peng,Marc Coram,Martin C. Stumpe,Derek Wu,Arunachalam Narayanaswamy,Subhashini Venugopalan,Kasumi Widner,Tom Madams,Jorge Cuadros,Ramasamy Kim,Rajiv Raman,Philip C. Nelson,Jessica L. Mega,Dale R. Webster +14 more
TL;DR: An algorithm based on deep machine learning had high sensitivity and specificity for detecting referable diabetic retinopathy and diabetic macular edema in retinal fundus photographs from adults with diabetes.
Journal ArticleDOI
Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
Robert J. Motzer,Bernard Escudier,David F. McDermott,Saby George,Hans J. Hammers,Sandhya Srinivas,Scott S. Tykodi,Jeffrey A. Sosman,Giuseppe Procopio,Elizabeth R. Plimack,Daniel Castellano,Toni K. Choueiri,Howard Gurney,Frede Donskov,Petri Bono,John Wagstaff,Thomas Gauler,Takeshi Ueda,Yoshihiko Tomita,Fabio A.B. Schutz,Christian Kollmannsberger,James Larkin,Alain Ravaud,Jason S. Simon,Li-an Xu,Ian M. Waxman,Padmanee Sharma +26 more
TL;DR: Overall survival was longer and fewer grade 3 or 4 adverse events occurred with nivolumab than with everolimus among patients with previously treated advanced renal-cell carcinoma.
Journal ArticleDOI
Two‐sided confidence intervals for the single proportion: comparison of seven methods
TL;DR: Criteria appropriate to the evaluation of various proposed methods for interval estimate methods for proportions include: closeness of the achieved coverage probability to its nominal value; whether intervals are located too close to or too distant from the middle of the scale; expected interval width; avoidance of aberrations such as limits outside [0,1] or zero width intervals; and ease of use.
Journal ArticleDOI
Approximate is Better than “Exact” for Interval Estimation of Binomial Proportions
Alan Agresti,Brent A. Coull +1 more
TL;DR: For example, this paper showed that using the adjusted Wald test with null rather than estimated standard error yields coverage probabilities close to nominal confidence levels, even for very small sample sizes, and that the 95% score interval has similar behavior as the adjusted-Wald interval obtained after adding two "successes" and two "failures" to the sample.
Journal ArticleDOI
Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma
Robert J. Motzer,Nizar M. Tannir,David F. McDermott,Osvaldo Arén Frontera,Bohuslav Melichar,Toni K. Choueiri,Elizabeth R. Plimack,Philippe Barthélémy,Camillo Porta,Saby George,Thomas Powles,Frede Donskov,V. Neiman,V. Neiman,Christian Kollmannsberger,Pamela Salman,Howard Gurney,Robert E. Hawkins,Alain Ravaud,Marc-Oliver Grimm,Sergio Bracarda,Carlos H. Barrios,Yoshihiko Tomita,Daniel Castellano,Brian I. Rini,Allen C. Chen,Sabeen Mekan,M. Brent McHenry,Megan Wind-Rotolo,Justin Doan,Padmanee Sharma,Hans J. Hammers,Hans J. Hammers,Bernard Escudier +33 more
TL;DR: Overall survival and objective response rates were significantly higher with nivolumab plus ipilimumab than with sunitinib among intermediate‐ and poor‐risk patients with previously untreated advanced renal‐cell carcinoma.
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Approximate is Better than “Exact” for Interval Estimation of Binomial Proportions
Alan Agresti,Brent A. Coull +1 more