Journal ArticleDOI
The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies
Inge Klinkenberg,Arjan Blokland +1 more
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TLDR
It is concluded that effects on learning and memory performance which are observed after higher doses of scopolamine are mediated by primary effects on attention and sensory/stimulus discrimination, and non-specific effects on behavior (e.g., locomotor activity, anxiety).About:
This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 2010-07-01. It has received 556 citations till now. The article focuses on the topics: Scopolamine Hydrobromide & Cognition.read more
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Acetylcholine and attention.
TL;DR: The role of ACh in cognition is different per brain region and between nicotinic versus muscarinic receptor subtypes, and in contrast, cholinergic signaling in the septohippocampal system is suggested to be involved in memory processes.
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A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice.
Andrea Wolf,Björn Bauer,Björn Bauer,Erin L. Abner,Tal Ashkenazy-Frolinger,Anika M.S. Hartz,Anika M.S. Hartz +6 more
TL;DR: A non-invasive behavioral test battery that allows detecting cognitive impairment in scopolamine-treated 129S6/SvEvTac mice and in transgenic 129S 6/Tg2576 mice is established.
Journal ArticleDOI
Selective Inhibition of Striatal Fast-Spiking Interneurons Causes Dyskinesias
Aryn H. Gittis,Daniel K. Leventhal,Benjamin A. Fensterheim,Jeffrey R. Pettibone,Joshua D. Berke,Anatol C. Kreitzer +5 more
TL;DR: Results provide direct evidence that hypofunction of striatal FSIs can produce movement abnormalities, and suggest that they may represent a novel therapeutic target for the treatment of hyperkinetic movement disorders.
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Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish.
Stefânia Konrad Richetti,Martina Blank,Katiucia Marques Capiotti,Angelo Luis Stapassoli Piato,Maurício Reis Bogo,Monica R. M. Vianna,Carla Denise Bonan +6 more
TL;DR: Investigation of the potential protective role of quercetin and rutin against scopolamine-induced inhibitory avoidance memory deficits in zebrafish contributes to the increase of the knowledge about plant compounds applicability as medicines to prevent and treat neurodegenerative diseases, like Alzheimer's disease.
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State of the Art of Anthocyanins: Antioxidant Activity, Sources, Bioavailability, and Therapeutic Effect in Human Health
TL;DR: The aim of this review is to provide an overview of advantages and disadvantages of the most common methods to determine the antioxidant activity of anthocyanins, chemical structure, and concentration of these compounds in different edible fruits, vegetables, and plants; their bioavailability after intake; as well as the main therapeutic effect described in the scientific literature.
References
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Book
The pharmacological basis of therapeutics
TL;DR: In this article, 42 authors share the herculean task of reviewing the flood of recent literature on pharmacology and rational use of drugs, under single or dual authorship they contribute the 76 chapters in the 18 sections.
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EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis
TL;DR: In this article, it is suggested to adjust the frequency windows of alpha and theta for each subject by using individual alpha frequency as an anchor point, based on this procedure, a consistent interpretation of a variety of findings is made possible.
Journal ArticleDOI
The Cholinergic Hypothesis of Geriatric Memory Dysfunction
Raymond T. Bartus,Raymond T. Bartus,Reginald L. Dean,Bernard Beer,Bernard Beer,Arnold S. Lippa,Arnold S. Lippa +6 more
TL;DR: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed and an attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature.
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Differential Contribution of Amygdala and Hippocampus to Cued and Contextual Fear Conditioning
R. G. Phillips,Joseph E. LeDoux +1 more
TL;DR: An associative roles for the amygdala and a sensory relay role for the hippocampus are suggested in fear conditioning, which is involved in the conditioning of fear responses to simple, modality-specific conditioned stimuli as well as to complex, polymodal stimuli.