Journal ArticleDOI
Therapeutic efficacy of three silver dressings in an infected animal model.
John P. Heggers,Rick E. Goodheart,J. W. Washington,Lana McCoy,Edith Carino,Thanh Dang,Pat Edgar,C Maness,David L. Chinkes,David L. Chinkes +9 more
Reads0
Chats0
TLDR
In this article, the authors focused on weekly dressing changes as a cost-containment issue and concluded that weekly dressing change with AgNO3 is feasible and medically congruous.Abstract:
The organic salt AgNO3 has been available as a topical armamentarium to the medical arena for centuries and for burns for the past 60 years. Thirty-five (1968) years later, Charles Fox introduced and popularized a new topical agent known as silver sulfadiazine. More recently, several new slow-release silver dressings came to the forefront. Acticoat (Smith & Nephew, Largo, FL) Silverlon (Argentum, Lakemont, GA) & Silvasorb (Medline Industries, Inc, Mundelein, IL). Because the standard of care is to change dressings daily, our study focused in on weekly dressing changes as a cost-containment issue. Sprague-Dawley rats received a standard contact burn (20% TBSA). On day 3, the wound was excised and infected with Pseudomonas aeruginosa and Staphylococcus aureus at 5.0 x 10 cfu/ml. The animals were divided into four groups (n = 5 each group): untreated control, Acticoat group, Silvasorb group, and Silverlon group. The dressings remained on the wounds for 10 days when the wounds were quantitatively assessed. Mean wound counts of the control ranged from 1.2 x 10(5) to 6.5 x 10(5) for P. aeruginosa and S. aureus, respectively. Acticoat dressing counts for both organisms were 0 and 1.8 x 10(3) (median alpha); Silvasorb was 0 and 6.3 x 10(3) and Silverlon was 1.5 x 10(4) x 7.4 x 10(4) (median), Acticoat and Silvasorb were both significantly lower (P < .05) than the control for P. aeruginosa, and Acticoat was significantly lower (P < .05) than the control for S. aureus. Although counts for Silvasorb (M) appear significantly lower than the controls for S. aureus, the numbers were not sufficient to be significant. However, Silverlon did achieve a slight significance. These preliminary data suggest that weekly dressing changes with these new silver dressings are feasible and economically and medically congruous.read more
Citations
More filters
Journal ArticleDOI
Burn Wound Infections
TL;DR: Improved outcomes for severely burned patients have been attributed to medical advances in fluid resuscitation, nutritional support, pulmonary and burn wound care, and infection control practices.
Journal ArticleDOI
Metal-based nanoparticles and their toxicity assessment.
Amanda M. Schrand,Mohammad F. Rahman,Saber M. Hussain,John J. Schlager,David A. Smith,Ali F. Syed +5 more
TL;DR: There are many challenges to overcome before the authors can determine if the benefits outweigh the risks associated with NPs, and some metal-based NPs are showing increased toxicity, even if the same material is relatively inert in its bulk form.
Journal ArticleDOI
Antibiotic-eluting medical devices for various applications
TL;DR: In this review emphasis is placed on processing techniques, microstructure, drug release profiles, biocompatibility and other relevant aspects necessary for advancing the therapeutic field of antibiotic-eluting devices.
Journal ArticleDOI
Antimicrobial activities of silver dressings: an in vitro comparison.
TL;DR: Understanding the characteristics of silver-coated or -impregnated dressings may enable them to be targeted more appropriately according to the specific requirements for use of a particular dressing, as in for prophylaxis in skin grafting or for an infected wound with MRSA.
Journal ArticleDOI
Silver dressings: their role in wound management.
TL;DR: There are good indications for the use of silver dressings, to remove or reduce an increasing bioburden in burns and open wounds healing by secondary intention, or to act as a barrier against cross contamination of resistant organisms such as MRSA.
References
More filters
Journal ArticleDOI
Multiple parameters for the comprehensive evaluation of the susceptibility of Escherichia coli to the silver ion
G J Zhao,S E Stevens +1 more
TL;DR: An evaluative model is presented as a reference for the quantitative analysis of the susceptibility of bacteria to silver ions and one log-unit of viable bacterial population size was lost every 30 min at the minimum bactericidal concentration of the silver ion.
Journal ArticleDOI
Treatment of large human burns with 0.5 per cent silver nitrate solution.
TL;DR: Although burns covering more than 65% of the body are still regularly but not always fatal, the fact that the relationship of mortality to the size of burn is ogival is reason to believe that ultimately even burns covering 90% to 100% ofThe body will not always be lethal.
Journal ArticleDOI
A matched-pair, randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds.
TL;DR: Acticoat dressing offers a new form of dressing for the burn wound, but it requires further investigation with greater numbers of patients in a larger number of centers and in different phases of burn wound care.
Journal ArticleDOI
A new technology of microdispersed silver in polyurethane induces antimicrobial activity in central venous catheters.
TL;DR: Silver ions have an affinity to sulfhydryl groups in enzyme systems of the cell wall, through which they interfere with the transmembranous energy transfer and electron transport of bacterial microorganisms, and block the respiratory chain of microorganisms reversibly in low concentrations and irreversibly in higher concentrations.
Journal ArticleDOI
Pharmacology and toxicology of heavy metals: Silver
TL;DR: Gold is found throughout the world in relatively pure form in lodes and placer deposits, as well as in impure form in many base metal ores, particularly in deposits of copper and silver as discussed by the authors.