THIOCYANATE: A potentially useful therapeutic agent with host defense and antioxidant properties
Joshua D. Chandler,Brian J. Day +1 more
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TLDR
An important endogenous molecule that has the potential to interact in complex and elegant ways with its host environment and foreign organisms, SCN's diverse properties as both host defense and antioxidant agent make it a potentially useful therapeutic.About:
This article is published in Biochemical Pharmacology.The article was published on 2012-12-01 and is currently open access. It has received 126 citations till now. The article focuses on the topics: Hypothiocyanite & Lactoperoxidase.read more
Citations
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Journal ArticleDOI
Inflammation and its genesis in cystic fibrosis.
David P. Nichols,James F. Chmiel +1 more
TL;DR: How protease and redox imbalance are critical factors in CF airway inflammation is discussed and some of the more promising therapeutic approaches now under development are reviewed.
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Mode of Action of Lactoperoxidase as Related to Its Antimicrobial Activity: A Review
TL;DR: This review describes briefly the classification of mammalian peroxidases and their role in the human immune system and in host cell damage, and summarizes present knowledge on the mode of action of lactoperoxidase.
Journal ArticleDOI
Topical Antimicrobials for Burn Infections – An Update
TL;DR: New patents in the areas of topically applied antibiotics and agents that can potentiate the action of existing antibiotics may extend their useful lifetime are brought up to date.
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Biochemical mechanisms and therapeutic potential of pseudohalide thiocyanate in human health.
Joshua D. Chandler,Brian J. Day +1 more
TL;DR: High oral bioavailability and an increased knowledge of the biochemical effects of SCN− on a subset of pro-inflammatory reactions suggest clinical utility, with implications for treatment of infectious lung disease and atherogenesis.
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Antimicrobial actions of dual oxidases and lactoperoxidase
TL;DR: A detailed, up-to-date summary of discoveries regarding antibacterial, antiviral, antifungal, and antiparasitic functions of DUOX enzymes is provided and all the literature describing the immune functions of lactoperoxidase is presented.
References
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Journal ArticleDOI
Protein carbamylation links inflammation, smoking, uremia and atherogenesis
Zeneng Wang,Stephen J. Nicholls,E. Rene Rodriguez,Outi Kummu,Sohvi Hörkkö,John Barnard,Wanda F Reynolds,Eric J. Topol,Eric J. Topol,Joseph A. DiDonato,Stanley L. Hazen +10 more
TL;DR: The discovery of an alternative and quantitatively dominant mechanism for cyanate formation and protein carbamylation at sites of inflammation and atherosclerotic plaque is reported: myeloperoxidase-catalyzed oxidation of thiocyanate, an anion abundant in blood whose levels are elevated in smokers.
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Thiocyanate and chloride as competing substrates for myeloperoxidase.
TL;DR: Thiocyanate is a major physiological substrate of myeloperoxidase, regardless of where the enzyme acts, and more consideration should be given to the oxidation products of thiOCyanate and to the role they play in host defence and inflammation.
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A novel host defense system of airways is defective in cystic fibrosis.
Patryk Moskwa,Daniel Lorentzen,Katherine J. D. A. Excoffon,Joseph Zabner,Paul B. McCray,William M. Nauseef,Corinne Dupuy,Botond Banfi +7 more
TL;DR: Data indicate a novel innate defense mechanism of airways that kills bacteria via ROS and suggest a new cellular and molecular basis for defective airway immunity in CF.
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Common themes and variations in the rhodanese superfamily
TL;DR: A superfamily of versatile proteins relying on persulfide chemistry to accomplish cellular functions spanning from resistance to environmental threats, such as cyanide, and key cellular reactions related to sulfur metabolism and progression of cell cycle is depicted.
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The peroxidase-thiocyanate-hydrogen peroxide antimicrobial system.
TL;DR: The peroxidase-thiocyanate-H 2 O 2 antimicrobial system in inhibited by catalase as well as by a number of low-molecular-weight substance which may be present in the growth media, or in biological fluids is considered.
Related Papers (5)
The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases
Yanping Xu,Szilvia Szép,Zhe Lu +2 more