Journal ArticleDOI
Time-of-Flight Mass Spectrometry and Gas-Liquid Partition Chromatography
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This article is published in Analytical Chemistry.The article was published on 1959-04-01. It has received 252 citations till now. The article focuses on the topics: Thermospray & Ion-mobility spectrometry–mass spectrometry.read more
Citations
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Use of a Mass Spectrometer as a Detector and Analyzer for Effluent Emerging from High Temperature Gas Liquid Chromatography Columns.
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New advances in separation science for metabolomics: resolving chemical diversity in a post-genomic era
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Tandem mass spectrometry in the study of fatty acids, bile acids, and steroids.
TL;DR: The FAB and ES ionization techniques will be discussed in relation to MS/MS, and examples of their application in biochemical studies will be presented.
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Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes.
TL;DR: A review of the application of mass spectrometry in the metabolomics pipeline can be found in this paper, where the current limitations of these platforms and applications are discussed with areas requiring further development also highlighted.
Journal ArticleDOI
Development and Performance of a Gas Chromatography−Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum
Paul Begley,Sue Francis-McIntyre,Warwick B. Dunn,David Broadhurst,Antony Halsall,Andy Tseng,Joshua Knowles,Royston Goodacre,Douglas B. Kell +8 more
TL;DR: A method for the preparation and GC-TOF-MS analysis of human serum samples has been developed and evaluated for application in long-term metabolomic studies and showed the ability to define metabolite differences between samples from a population and samples spiked with metabolites standards.
References
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Journal ArticleDOI
Time-of-flight mass spectrometer with improved resolution
W. C. Wiley,I. H. McLaren +1 more
TL;DR: In this paper, a new type of ion gun is described which greatly improves the resolution of a nonmagnetic time-of-flight mass spectrometer, and the focusing action of this gun is discussed and analyzed mathematically.
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Mass Spectrometric Analysis Broad Applicability to Chemical Research
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Gas chromatography. I. The separation and estimation of volatile organic compounds by gas-liquid partition chromatography
TL;DR: An extension of the work of James and Martin on the separation of volatile fatty acids and bases by gas-liquid partition chromatography is described in this paper, which has been applied to the analysis of most types of volatile organic compounds on a milligram scale.
Journal ArticleDOI
Mass Spectrometric Analysis Aliphatic Aldehydes
J. A. Gilpin,Fred W. McLafferty +1 more
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Use of a Mass Spectrometer as a Detector and Analyzer for Effluent Emerging from High Temperature Gas Liquid Chromatography Columns.
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