Journal ArticleDOI
New advances in separation science for metabolomics: resolving chemical diversity in a post-genomic era
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This article is published in Chemical Reviews.The article was published on 2013-03-18. It has received 287 citations till now. The article focuses on the topics: Mass spectrometry & Metabolomics.read more
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Drug Discovery Today
TL;DR: A wide range of new lead finding and lead optimization opportunities result from novel screening methods by NMR, which are the topic of this review article.
Journal ArticleDOI
Metabolomics: an emerging but powerful tool for precision medicine.
TL;DR: Current metabolomic technologies go well beyond the scope of standard clinical chemistry techniques and are capable of precise analyses of hundreds to thousands of metabolites, which affords detailed characterization of metabolic phenotypes and can enable precision medicine at a number of levels.
Journal ArticleDOI
Metabolite Measurement: Pitfalls to Avoid and Practices to Follow
TL;DR: The common pitfalls encountered in metabolomics are reviewed and concrete guidelines for obtaining accurate metabolite measurements are provided, focusing on water-soluble primary metabolites.
Journal ArticleDOI
Two-Dimensional Liquid Chromatography: A State of the Art Tutorial
Dwight R. Stoll,Peter W. Carr +1 more
TL;DR: This tutorial discusses the motivations for doing two-dimensional liquid chromatography and describes the commonly used implementations of the method, and discusses the state of the art in 2D-LC performance as measured by peak capacity.
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Optimized Analytical Procedures for the Untargeted Metabolomic Profiling of Human Urine and Plasma by Combining Hydrophilic Interaction (HILIC) and Reverse-Phase Liquid Chromatography (RPLC)–Mass Spectrometry
TL;DR: Combining the optimal HILIC- and RPLC-MS approaches improve the comprehensiveness of global metabolic profiling of body fluids and thus are valuable for monitoring and discovering metabolic changes associated with health and disease in clinical research studies.
References
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High resolution two-dimensional electrophoresis of proteins.
TL;DR: This technique provides a method for estimation of the number of proteins made by any biological system and can resolve proteins differing in a single charge and consequently can be used in the analysis of in vivo modifications resulting in a change in charge.
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The sequence of the human genome.
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TL;DR: Comparative genomic analysis indicates vertebrate expansions of genes associated with neuronal function, with tissue-specific developmental regulation, and with the hemostasis and immune systems are indicated.
Journal ArticleDOI
Electrospray ionization for mass spectrometry of large biomolecules
TL;DR: Spectra have been obtained for biopolymers including oligonucleotides and proteins, the latter having molecular weights up to 130,000, with as yet no evidence of an upper limit.
Journal ArticleDOI
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.
Fleischmann Rd,Adams,Owen White,Rebecca A. Clayton,Ewen F. Kirkness,Anthony R. Kerlavage,Carol J. Bult,J F Tomb,Brian Dougherty,Merrick Jm +9 more
TL;DR: An approach for genome analysis based on sequencing and assembly of unselected pieces of DNA from the whole chromosome has been applied to obtain the complete nucleotide sequence of the genome from the bacterium Haemophilus influenzae Rd.
Journal ArticleDOI
Life with 6000 Genes
André Goffeau,Bart Barrell,Howard Bussey,Ronald W. Davis,Bernard Dujon,Horst Feldmann,Francis Galibert,J D Hoheisel,Claude Jacq,Mark Johnston,Edward J. Louis,Hans-Werner Mewes,Yasufumi Murakami,Peter Philippsen,Hervé Tettelin,Stephen G. Oliver +15 more
TL;DR: The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration and provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history.