Journal ArticleDOI
Titanocene(II)-promoted stereoselective alkenylation utilizing (Z)-alkenyl sulfones.
TLDR
This alkenylation system is also applicable to polar C=O bonds; the simple mixing of carbonyl compounds, (Z)-alkenyl methyl sulfones, and the titanocene(II) reagent formed allylic alcohols.Abstract:
The stereoselective alkenylation of unsaturated compounds by means of a (Z)-alkenyl sulfone-titanocene(II) system is described. Treatment of alkynes and (Z)-alkenyl methyl sulfones with the titanocene(II) reagent Cp2Ti[P(OEt)3]2 produced conjugated dienes. This alkenylation system is also applicable to polar CO bonds; the simple mixing of carbonyl compounds, (Z)-alkenyl methyl sulfones, and the titanocene(II) reagent formed allylic alcohols. The advantages of alkenylation are that it requires no prepreparation of the alkenylmetal reagent and that it proceeds with complete stereoselectivity.read more
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Book ChapterDOI
Recent advances in stereoselective synthesis of 1,3-dienes.
TL;DR: The aim of this review is to present the latest developments in the stereoselective synthesis of conjugated dienes, covering the period 2005-2010, and illustrates the most representative strategies and mechanisms to access these targets.
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Catalytic highly enantioselective alkylation of aldehydes with deactivated grignard reagents and synthesis of bioactive intermediate secondary arylpropanols.
TL;DR: Important intermediate secondary arylpropanols for chiral drug synthesis were effectively synthesized with high enantioselectivity, up to 97%, in one step.
Journal ArticleDOI
Chemoselective and direct functionalization of methyl benzyl ethers and unsymmetrical dibenzyl ethers by using iron trichloride.
TL;DR: The present methodologies provide not only a novel chemoselectivity but also the advantage of shortened synthetic steps, due to the direct process without the deprotection of the methyl and benzyl ethers.
Journal ArticleDOI
The chemistry of the carbon-transition metal double and triple bond: Annual survey covering the Year 2007 ☆
TL;DR: A review of papers published in the year 2007 that focus on the synthesis, reactivity, or properties of compounds containing a carbon-transition metal double or triple bond can be found in this paper.
Journal ArticleDOI
Transformation of alkynyl sulfones into alkynylphosphonates with trialkyl phosphites
TL;DR: In this paper, 1-Alkynylphosphonates were obtained in good to high yields by simple heating of 1-alkynyl sulfones with trialkyl phosphites.
References
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