Journal ArticleDOI
TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria.
Dominic P. Kwiatkowski,Adrian V. S. Hill,I. Sambou,P. Twumasi,J. Castracane,K. R. Manogue,Anthony Cerami,David Brewster,Brian Greenwood +8 more
TLDR
It is concluded that increased TNF production is a normal host response to P falciparum infection, but that excessive levels of production may predispose to cerebral malaria and a fatal outcome.About:
This article is published in The Lancet.The article was published on 1990-11-17. It has received 861 citations till now. The article focuses on the topics: Cerebral Malaria & Plasmodium falciparum.read more
Citations
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Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation
TL;DR: It is demonstrated, with reporter genes under the control of the two allelic TNF promoters, that TNF2 is a much stronger transcriptional activator than the common allele (TNF1) in a human B cell line.
Journal ArticleDOI
TNF‐mediated inflammatory disease
TL;DR: The central role of TNF in inflammation has been demonstrated by the ability of agents that block the action of T NF to treat a range of inflammatory conditions, including rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease and psoriasis.
Journal ArticleDOI
Common West African HLA antigens are associated with protection from severe malaria
Adrian V. S. Hill,Catherine E. M. Allsopp,Dominic P. Kwiatkowski,Nicholas M. Anstey,Patrick Twumasi,P. Rowe,Stephen Bennett,David Brewster,Andrew J. McMichael,Brian M. Greenwood +9 more
TL;DR: Data support the hypothesis that the extraordinary polymorphism of major histocompatibility complex genes has evolved primarily through natural selection by infectious pathogens.
Journal ArticleDOI
Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.
William McGuire,Adrian V. S. Hill,Catherine E. M. Allsopp,Brian Greenwood,Dominic P. Kwiatkowski +4 more
TL;DR: The maintenance of the TNF2 allele at a gene frequency of 0.16 in The Gambia implies that the increased risk of cerebral malaria in homozygotes is counterbalanced by some biological advantage, suggesting that regulatory polymorphisms of cytokine genes can affect the outcome of severe infection.
Journal ArticleDOI
Multifactorial nature of human immunodeficiency virus disease: implications for therapy
TL;DR: The immunopathogenic mechanisms underlying human immunodeficiency virus (HIV) disease are extremely complex; the disease process is multifactorial with multiple overlapping phases as mentioned in this paper, and therapeutic strategies in HIV disease must not be unidimensional, but rather must be linked to the complex pathogenic components of the disease and must address where feasible each of the recognized pathogenic processes for the possibility of therapeutic intervention.
References
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Journal Article
Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.
Junming Le,Jan Vilcek +1 more
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Molecular cloning and expression of a receptor for human tumor necrosis factor.
Thomas J. Schall,Martyn Lewis,Kerry J. Koller,Angela Lee,Glenn C. Rice,Grace H. W. Wong,Tetsuya Gatanaga,Gale A. Granger,Rigdon Lentz,Helga Raab,William J. Kohr,David V. Goeddel +11 more
TL;DR: Northern analysis indicates a single species of mRNA for the TNF-R in a variety of cell types, therefore, the soluble TNF binding protein found in human serum is probably proteolytically derived from the T NF-R.
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Tumor Necrosis Factor and Disease Severity in Children with Falciparum Malaria
Georges E. Grau,Terrie E. Taylor,Malcolm E. Molyneux,Jack J. Wirima,Pierre Vassalli,Marcel Hommel,Paul-Henri Lambert +6 more
TL;DR: The level of tumor necrosis factor is frequently increased in patients with severe falciparum malaria, particularly in those with cerebral malaria or hypoglycemia, and whether it is important in the pathogenesis of the signs and symptoms of the disease requires further study.
Journal Article
Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo.
TL;DR: Electrophoretic analysis of tissues recovered from injected animals suggests that the hormone is very rapidly degraded after binding, andCachectin/TNF bioactivity was monitored in the same serum samples by measuring lipoprotein lipase (LPL) suppression in 3T3-L1 cells.
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Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria.
Georges E. Grau,Luis F. Fajardo,Pierre-François Piguet,Bernard Allet,Paul-Henri Lambert,Pierre Vassalli +5 more
TL;DR: Results indicate that TNF-alpha has an important role in the pathogenesis of cerebral malaria in this murine model and suggest that local accumulation and activation of macrophages may lead to the predominance of lesions in the central nervous system.