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Anthony G. Wilson
Researcher at University College Dublin
Publications - 221
Citations - 16097
Anthony G. Wilson is an academic researcher from University College Dublin. The author has contributed to research in topics: Rheumatoid arthritis & Arthritis. The author has an hindex of 59, co-authored 202 publications receiving 15135 citations. Previous affiliations of Anthony G. Wilson include University of Manchester & Manchester Royal Infirmary.
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Journal ArticleDOI
Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation
TL;DR: It is demonstrated, with reporter genes under the control of the two allelic TNF promoters, that TNF2 is a much stronger transcriptional activator than the common allele (TNF1) in a human B cell line.
Journal ArticleDOI
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
Eli A. Stahl,Soumya Raychaudhuri,Soumya Raychaudhuri,Elaine F. Remmers,Gang Xie,Stephen Eyre,Brian Thomson,Yonghong Li,Fina A S Kurreeman,Fina A S Kurreeman,Fina A S Kurreeman,Alexandra Zhernakova,Anne Hinks,Candace Guiducci,Robert Chen,Lars Alfredsson,Christopher I. Amos,Kristin G. Ardlie,Anne Barton,John Bowes,Elisabeth Brouwer,Noël P. Burtt,Joseph J. Catanese,Jonathan S. Coblyn,Marieke J H Coenen,Karen H. Costenbader,Lindsey A. Criswell,J. Bart A. Crusius,Jing Cui,Paul I.W. de Bakker,Paul I.W. de Bakker,Philip L. De Jager,Philip L. De Jager,Bo Ding,Paul Emery,Edward Flynn,Pille Harrison,Lynne J. Hocking,Tom W J Huizinga,Daniel L. Kastner,Xiayi Ke,Annette Lee,Xiangdong Liu,Paul Martin,Ann W. Morgan,Leonid Padyukov,Marcel D. Posthumus,Timothy R D J Radstake,David M. Reid,Mark Seielstad,Michael F. Seldin,Nancy A. Shadick,Sophia Steer,Paul P. Tak,Wendy Thomson,Annette H M van der Helm-van Mil,Irene E. van der Horst-Bruinsma,C. Ellen van der Schoot,Piet L. C. M. van Riel,Michael E. Weinblatt,Anthony G. Wilson,Gertjan Wolbink,B. Paul Wordsworth,Cisca Wijmenga,Elizabeth W. Karlson,René E. M. Toes,Niek de Vries,Ann B. Begovich,Ann B. Begovich,Jane Worthington,Katherine A. Siminovitch,Peter K. Gregersen,Lars Klareskog,Robert M. Plenge,Robert M. Plenge +74 more
TL;DR: Seven new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 × 10−8) in an analysis of all 41,282 samples, and an additional 11 SNPs replicated at P < 0.05, suggesting that most represent genuine rhearatoid arthritisrisk alleles.
Journal ArticleDOI
Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product.
Journal ArticleDOI
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
Nicholas John Craddock,Matthew E. Hurles,Niall Cardin,Richard D. Pearson,Vincent Plagnol,Samuel Robson,Damjan Vukcevic,Chris P. Barnes,Donald F. Conrad,Eleni Giannoulatou,Christopher Holmes,Jonathan Marchini,Kathy Stirrups,Martin D. Tobin,Louise V. Wain,Christopher Yau,Jan Aerts,Tariq Ahmad,T. Daniel Andrews,Hazel Arbury,Anthony Attwood,Anthony Attwood,Anthony Attwood,Adam Auton,Stephen G. Ball,Anthony J. Balmforth,Jeffrey C. Barrett,Inês Barroso,Anne Barton,Amanda J. Bennett,Sanjeev S. Bhaskar,Katarzyna Blaszczyk,John Bowes,Oliver J. Brand,Peter S. Braund,Francesca Bredin,Gerome Breen,Gerome Breen,Morris J. Brown,Ian N. Bruce,Jaswinder Bull,Oliver S. Burren,John Burton,Jake K. Byrnes,Sian Caesar,Chris Clee,Alison J. Coffey,John M. C. Connell,Jason D. Cooper,Anna F. Dominiczak,Kate Downes,Hazel E. Drummond,Darshna Dudakia,Andrew Dunham,Bernadette Ebbs,Diana Eccles,Sarah Edkins,Cathryn Edwards,Anna Elliot,Paul Emery,David M. Evans,Gareth Evans,Steve Eyre,Anne Farmer,I. Nicol Ferrier,Lars Feuk,Lars Feuk,Tomas W Fitzgerald,Edward Flynn,Alistair Forbes,Liz Forty,Jayne A. Franklyn,Jayne A. Franklyn,Rachel M. Freathy,Polly Gibbs,Paul Gilbert,Omer Gokumen,Katherine Gordon-Smith,Katherine Gordon-Smith,Emma Gray,Elaine K. Green,Christopher J. Groves,Detelina Grozeva,Rhian Gwilliam,A Hall,Naomi Hammond,Matthew Hardy,Pile Harrison,Neelam Hassanali,Husam Hebaishi,Sarah Hines,Anne Hinks,Graham A. Hitman,Lynne J. Hocking,Eleanor Howard,Philip Howard,Joanna M. M. Howson,Debbie Hughes,Sarah E. Hunt,John D. Isaacs,Mahim Jain,Derek P. Jewell,Toby Johnson,Jennifer Jolley,Jennifer Jolley,Ian Jones,Lisa Jones,George Kirov,Cordelia Langford,Hana Lango-Allen,G. Mark Lathrop,James Lee,Kate L. Lee,Charlie W. Lees,Kevin Lewis,Cecilia M. Lindgren,Meeta Maisuria-Armer,Julian Maller,John C. Mansfield,Paul Martin,Dunecan Massey,Wendy L. McArdle,Peter McGuffin,Kirsten McLay,Alexander J. Mentzer,Michael L. Mimmack,Ann E. Morgan,Andrew P. Morris,Craig Mowat,Simon Myers,William G. Newman,Elaine R. Nimmo,Michael Conlon O'Donovan,Abiodun Onipinla,Ifejinelo Onyiah,Nigel R. Ovington,Michael John Owen,Kimmo Palin,Kirstie Parnell,David Pernet,John R. B. Perry,Anne M. Phillips,Dalila Pinto,Natalie J. Prescott,Inga Prokopenko,Michael A. Quail,Suzanne Rafelt,Nigel W. Rayner,Richard Redon,David M. Reid,Anthony Renwick,Susan M. Ring,Neil Robertson,E. Russell,David St Clair,Jennifer G. Sambrook,Jennifer G. Sambrook,Jeremy D. Sanderson,Helen Schuilenburg,Carol Scott,Richard T. Scott,Sheila Seal,Sue Shaw-Hawkins,Beverley M. Shields,Matthew J. Simmonds,Debbie J. Smyth,Elilan Somaskantharajah,Katarina Spanova,Sophia Steer,Jonathan Stephens,Jonathan Stephens,Helen Stevens,Millicent A. Stone,Millicent A. Stone,Zhan Su,Deborah P M Symmons,John R. Thompson,Wendy Thomson,Mary E. Travers,Clare Turnbull,Armand Valsesia,Mark Walker,Neil Walker,Chris Wallace,Margaret Warren-Perry,Nicholas A. Watkins,Nicholas A. Watkins,John Webster,Michael N. Weedon,Anthony G. Wilson,Matthew Woodburn,B. Paul Wordsworth,Allan H. Young,Allan H. Young,Eleftheria Zeggini,Eleftheria Zeggini,Nigel P. Carter,Timothy M. Frayling,Charles Lee,Gil McVean,Patricia B. Munroe,Aarno Palotie,Stephen Sawcer,Stephen W. Scherer,David P. Strachan,Chris Tyler-Smith,Matthew A. Brown,Matthew A. Brown,Paul Burton,Mark J. Caulfield,Alastair Compston,Martin Farrall,Stephen C. L. Gough,Stephen C. L. Gough,Alistair S. Hall,Andrew T. Hattersley,Adrian V. S. Hill,Christopher G. Mathew,Marcus Pembrey,Jack Satsangi,Michael R. Stratton,Jane Worthington,Panos Deloukas,Audrey Duncanson,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Mark I. McCarthy,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Miles Parkes,Nazneen Rahman,John A. Todd,Nilesh J. Samani,Nilesh J. Samani,Peter Donnelly +235 more
TL;DR: A large, direct genome-wide study of association between CNVs and eight common human diseases concludes that common CNVs that can be typed on existing platforms are unlikely to contribute greatly to the genetic basis ofcommon human diseases.
Journal ArticleDOI
An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles.
Anthony G. Wilson,N. de Vries,Flemming Pociot,F. S. Di Giovine,L. B. A. Van Der Putte,Gordon W. Duff +5 more
TL;DR: Frequency analysis of the TNF-alpha polymorphism, using the polymerase chain reaction and single-stranded conformational polymorphism in HLA-typed individuals, reveals a very strong association between the uncommon TNF allele and HLA A1, B8, and DR3 alleles.