Journal ArticleDOI
Toxicity of natural and synthetic pyrethrins to rats
R.D. Verschoyle,J.M. Barnes +1 more
TLDR
In this paper, natural pyrethrins and five synthetic analogs were given intravenously and orally to rats and the ratio of the acute toxicity by the two routes varied considerably.About:
This article is published in Pesticide Biochemistry and Physiology.The article was published on 1972-10-01. It has received 116 citations till now. The article focuses on the topics: Acute toxicity & Toxicity.read more
Citations
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Journal ArticleDOI
Mechanisms of pyrethroid neurotoxicity: Implications for cumulative risk assessment
David M. Soderlund,John M. Clark,Larry P. Sheets,Linda S. Mullin,Vincent J Piccirillo,Dana Sargent,James T Stevens,Myra L. Weiner +7 more
TL;DR: The diverse toxic actions and pharmacological effects of pyrethroids suggest that simple additivity models based on combined actions at a single target are not appropriate to assess the risks of cumulative exposure to multiple pyre Throids.
Journal ArticleDOI
Developmental Neurotoxicity of Pyrethroid Insecticides: Critical Review and Future Research Needs
TL;DR: To better understand the potential for developmental exposure to pyrethroids to cause neurotoxicity, additional, well-designed and well-executed developmental neurotoxicity studies are needed.
Journal ArticleDOI
Mechanisms of selective action of pyrethroid insecticides.
Journal ArticleDOI
Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances
TL;DR: A critical re-evaluation of the role of these three targets in pyrethroid neurotoxicity is provided based on information published during the past decade on the action of pyrethroids on voltage-gated calcium and chloride channels.
Journal ArticleDOI
The future of pyrethroids in insect control
TL;DR: The more stable synthetic pyrethroids, the main subject of this review, are based on the earlier natural and synthetic pyrethrins, but differ so markedly from them in properties and activity as to constitute a new class of insecticides.
References
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Tables for Convenient Calculation of Median-Effective Dose (LD50 or ED50) and Instructions in their Use.
Journal Article
Mode of action of pyrethroids.
TL;DR: Detailed analyses of the action of allethrin on the giant axons of the cockroach, the crayfish, and the squid performed by means of intracellular microelectrode and voltage clamp methods have revealed the ionic basis of theaction of allelethrinon on the nerve.
Journal ArticleDOI
Interaction of DDT with the components of lobster nerve membrane conductance.
Toshio Narahashi,Hans G. Haas +1 more
TL;DR: The finding that, under the influence of DDT, the steady-state current starts flowing while the peak transient current is partially maintained supports the hypothesis of two operationally separate ion channels in the nerve membrane.
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5-Benzyl-3-furylmethyl Chrysanthemate: a New Potent Insecticide
TL;DR: The (±)-cis-trans-clarysanthemate (m.p. 43–48°) is the most toxic compound tested so far, of any class of insecticide, to 1–2 day old unfed females of Anopheles stephensi and Aedes aegypti.
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Oxidative metabolism of pyrethrins in mammals.
TL;DR: Examination of the degradation of pyrethrin I and ofpyrethrin II in rats fed separately with large amounts of pure tritium-labelled pyrethrins I and II showed that each of the principal metabolites retains the cyclopropane ester linkage and is formed by modification of both the acid and alcohol moieties.