Journal ArticleDOI
Mechanisms of pyrethroid neurotoxicity: Implications for cumulative risk assessment
David M. Soderlund,John M. Clark,Larry P. Sheets,Linda S. Mullin,Vincent J Piccirillo,Dana Sargent,James T Stevens,Myra L. Weiner +7 more
TLDR
The diverse toxic actions and pharmacological effects of pyrethroids suggest that simple additivity models based on combined actions at a single target are not appropriate to assess the risks of cumulative exposure to multiple pyre Throids.About:
This article is published in Toxicology.The article was published on 2002-02-01. It has received 849 citations till now. The article focuses on the topics: Neurotoxicity Syndrome & Toxic Actions.read more
Citations
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Journal ArticleDOI
Neuroactive Insecticides: Targets, Selectivity, Resistance, and Secondary Effects
TL;DR: Primary toxic effects in mammals from off-target serine hydrolase inhibition include organophosphate-induced delayed neuropathy and disruption of the cannabinoid system.
Journal ArticleDOI
Developmental Neurotoxicity of Pyrethroid Insecticides: Critical Review and Future Research Needs
TL;DR: To better understand the potential for developmental exposure to pyrethroids to cause neurotoxicity, additional, well-designed and well-executed developmental neurotoxicity studies are needed.
Journal ArticleDOI
Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances
TL;DR: A critical re-evaluation of the role of these three targets in pyrethroid neurotoxicity is provided based on information published during the past decade on the action of pyrethroids on voltage-gated calcium and chloride channels.
Journal ArticleDOI
Urinary concentrations of metabolites of pyrethroid insecticides in the general U.S. population: National Health and Nutrition Examination Survey 1999-2002.
Dana B. Barr,Anders O. Olsson,Lee Yang Wong,Simeon O. Udunka,Samuel E. Baker,Ralph D. Whitehead,Melina S. Magsumbol,Bryan L. Williams,Larry L. Needham +8 more
TL;DR: The presence of its metabolites in the urine of U.S. residents indicates that children may have higher exposures to pyrethroid insecticides than adolescents and adults, and the presence of 3-phenoxybenzoic acid, a metabolite common to many pyrethoid insecticides, in more than 70% of the samples.
Journal ArticleDOI
Neurotoxicity of pesticides: a brief review.
TL;DR: The effects of pesticides on the nervous system may be involved in their acute toxicity, as in case of most insecticides, or may contribute to chronic neurodegenerative disorders, most notably Parkinson's disease.
References
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Journal ArticleDOI
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
William A. Catterall,K. G. Chandy,David E. Clapham,George A. Gutman,Franz Hofmann,Anthony J. Harmar,Darrell R. Abernethy,Michael Spedding +7 more
TL;DR: This issue of Pharmacological Reviews includes a new venture in the collaboration between the International Union of Pharmacology (IUPHAR) and the American Society for Pharmacology and Experimental Therapeutics (ASPET), in that a new classification of voltage-gated ion channels is outlined.
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GABAA Receptor Channels
TL;DR: This chapter discusses the gamma-aminobutyric acid (GABA) receptor channels, which are the most abundant inhibitory neurotransmitter in the CNS.
Journal Article
International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.
Eric A. Barnard,P. Skolnick,Richard W. Olsen,H. Mohler,W. Sieghart,G. Biggio,C. Braestrup,A. N. Bateson,S. Z. Langer +8 more
TL;DR: This article does not aim to review in detail the properties of γ-aminobutyric acidA(GABAA)breceptors, but in this same journal, a review of the binding properties and pharmacology of these receptors has been published.
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Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding
TL;DR: Specific [3H]diazepam binding to membranes appears to be restricted to brain, where it is unevenly distributed: the density of diazepam receptors is about five times higher in cortex (the highest density) than in pons-meddula (lowest density).
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A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons
TL;DR: A 1,957 amino-acid sodium channel is identified in dorsal root ganglion sensory neurons associated with C-fibres that shows 65% identity with the rat cardiac tetrodotoxin-insensitive sodium channel, and is not expressed in other peripheral and central neurons, glia or non-neuronal tissues.