Dana Sargent

TL;DR: The diverse toxic actions and pharmacological effects of pyrethroids suggest that simple additivity models based on combined actions at a single target are not appropriate to assess the risks of cumulative exposure to multiple pyre Throids.

TL;DR: Overall, based upon neurotoxicity data and the effect of pyrethroids on sodium, calcium and chloride ion channels, it is proposed that bioallethrin, cismethrin, tefluthrin, bifenthrin and permethrin belong to one common mechanism group and deltamethrine, lambda-cyhalothrin, cy Fluthrin and cypermethrin belonging to a second.

TL;DR: Signs of neurotoxicity in vivo are established that can be used as weight of evidence to determine whether pyrethroid insecticides act through a common mechanism of toxicity in mammals.

TL;DR: This article evaluated key references in the area of pediatric risk to identify a spectrum of methodological approaches and these approaches are considered for their potential to be extrapolated for the identification and assessment of other sensitive populations.

TL;DR: The evaluation demonstrated the concept of using existing information within the RISK21 matrix to drive the generation of additional data using a value-of-information approach and showed how new methodology such as the use of in vitro studies and assays could be used to answer the specific questions which arise through the useof the matrix.