Open AccessJournal Article
Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis.
TLDR
Since magnesium regulates calcium transport, and magnesium replacement in magnesium-deficient postmenopausal patients resulted in unexpected improvement in documented osteoporosis, this investigation investigated the effect of magnesium treatment on trabecular bone density in post menopausal osteoporeosis.Abstract:
Since magnesium regulates calcium transport, and magnesium replacement in magnesium-deficient postmenopausal patients resulted in unexpected improvement in documented osteoporosis, we investigated the effect of magnesium treatment on trabecular bone density in postmenopausal osteoporosis. Thirty-one postmenopausal patients (mean age +/- SD = 57.6 +/- 10.6 years), consecutively admitted to the Back Rehabilitation Unit with musculoskeletal pain of non-malignant origin and bone density values of 0.05). The mean bone density of the responders increased significantly both after one year (P < 0.001) and after 2 years (P < 0.02), while in untreated controls, the mean bone density decreased significantly (P < 0.001). The disparity between the initial mean bone density and bone density after one year in all osteoporotic patients and in the responders differed significantly from that of the controls (both P < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)read more
Citations
More filters
Journal ArticleDOI
Magnesium in Man: Implications for Health and Disease
TL;DR: An extensive and comprehensive overview of Mg(2+) research over the last few decades is provided, focusing on the regulation of M g(2+) homeostasis in the intestine, kidney, and bone and disturbances which may result in hypomagnesemia.
Journal ArticleDOI
Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women
Katherine L. Tucker,Marian T. Hannan,Honglei Chen,L. A. Cupples,P. W. F. Wilson,Douglas P. Kiel +5 more
TL;DR: The hypothesis that alkaline-producing dietary components, specifically, potassium, magnesium, and fruit and vegetables, contribute to maintenance of BMD is supported.
Journal ArticleDOI
Magnesium: nutrition and metabolism.
TL;DR: Due to the growing knowledge about the regulation of extra- and intracellular magnesium concentrations and the effects of changed extracellular magnesium levels the use of magnesium in therapy gains more widespread attention.
Journal ArticleDOI
Nutrition in bone health revisited: a story beyond calcium
TL;DR: The role of dietary components on bone health throughout different stages of life is reviewed, however the fact that many nutrients are co-dependent and simultaneously interact with genetic and environmental factors should not be neglected.
References
More filters
Journal ArticleDOI
Intermittent cyclical etidronate treatment of postmenopausal osteoporosis.
Nelson B. Watts,S. T. Harris,Harry K. Genant,Richard D. Wasnich,Paul D. Miller,Rebecca D. Jackson,A.A. Licata,Philip D. Ross,G C Woodson rd,M. J. Yanover +9 more
TL;DR: A prospective, two-year, double-blind, placebo-controlled, multicenter study in 429 women who had one to four vertebral compression fractures plus radiographic evidence of osteopenia to determine the effects of etidronate in the treatment of postmenopausal osteoporosis.
Journal ArticleDOI
Treatment of Postmenopausal Osteoporosis with Transdermal Estrogen
Edward G. Lufkin,Heinz W. Wahner,William M. O'Fallon,Stephen F. Hodgson,Mark A. Kotowicz,Ann W. Lane,Howard L. Judd,Robert H. Caplan,B. Lawrence Riggs +8 more
TL;DR: Transdermal estradiol treatment is effective in postmenopausal women with established osteoporosis and vertebral fractures and Histomorphometric evaluation of iliac biopsy samples confirmed the effect of estrogen on bone formation rate per bone volume.
Journal ArticleDOI
Prevention of early postmenopausal bone loss: controlled 2-year study in 315 normal females.
Claus Christiansen,M. S. Christensen,Peter McNair,Claus Hagen,Knud-Erik Stocklund,Ib Transbøl +5 more
TL;DR: This study randomized 315 healthy volunteers in their early natural menopause to seven treatment and three placebo groups, with the aim of preventing postmenopausal bone loss.
Journal ArticleDOI
Does calcium supplementation prevent postmenopausal bone loss? A double-blind, controlled clinical study.
TL;DR: The preliminary data suggest that calcium supplementation in the dosage used is not as effective as estrogen therapy for the prevention of early postmenopausal bone loss.
Journal ArticleDOI
Evidence for efficacy of drugs affecting bone metabolism in preventing hip fracture.
John A. Kanis,Olof Johnell,Bo Gullberg,E. Allander,Güzin Dilşen,Carlo Gennari,A. Lopes Vaz,George P. Lyritis,Gianfranco Mazzuoli,L. Miravet +9 more
TL;DR: Oestrogen, calcium, and calcitonins significantly decrease the risk of hip fracture, and short term intervention late in the natural course of osteoporosis may have significant effects on the incidence of hip fractures.