Journal ArticleDOI
Translation of the UGA triplet in vitro by tryptophan transfer RNA's
David Hirsh,Larry Gold +1 more
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Purified tRNATrp stimulates lysozyme synthesis 30-fold above the level seen when comparable amounts of tryptophan tRNA from the non-suppressing strain, CA244, were added; it also translates poly(U-G-A) as polytryptophan more efficiently than the su− tRNA.About:
This article is published in Journal of Molecular Biology.The article was published on 1971-06-14. It has received 142 citations till now. The article focuses on the topics: Transfer RNA & RNA.read more
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The 3′-Terminal Sequence of Escherichia coli 16S Ribosomal RNA: Complementarity to Nonsense Triplets and Ribosome Binding Sites
John Shine,Lynn Dalgarno +1 more
TL;DR: It is suggested that this region of the RNA is able to interact with mRNA and that the 3'-terminal U-U-A(OH) is involved in the termination of protein synthesis through base-pairing with terminator codons.
Journal ArticleDOI
Structural insights into translational fidelity
James M. Ogle,Venki Ramakrishnan +1 more
TL;DR: A large body of data on the effect of antibiotics and mutations on translational fidelity is explained, such as the mechanism of activation of GTP hydrolysis by EF-Tu, and the relationship between decoding and frameshifting.
Journal ArticleDOI
A different genetic code in human mitochondria
TL;DR: Comparison of the human mitochrondrial DNA sequence of the cytochrome oxidase subunit II gene and the sequence of a corresponding beef heart protein shows that UGA is used as a tryptophan codon and not as a termination codon, and suggests that AU A may be a methionine and not an isoleucine codon.
Journal ArticleDOI
Errors and alternatives in reading the universal genetic code.
TL;DR: Discussion sur les erreurs faux-sens, les mecanismes de terminaison and de decalages de lecture and les moyens dont dispose la cellule pour controler and s'accommoder de ces erreur.
Journal ArticleDOI
Complete Nucleotide Sequence of the Genomic RNA of Sindbis Virus
TL;DR: The entire nucleotide sequence of the genomic RNA of the type virus of the alphavirus genus, Sindbis virus, has been determined and a replication strategy based upon the completeucleotide sequence, as well as prior data, is presented.
References
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Journal ArticleDOI
A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counter
TL;DR: A modification of the naphthalene-dioxane-PPO liquid scintillator has been described which will allow up to 3.0 ml of an aqueous solution to be counted as mentioned in this paper.
Journal ArticleDOI
Rna codewords and protein synthesis. the effect of trinucleotides upon the binding of srna to ribosomes.
TL;DR: Property of the codeword recognition process and the minimum oligonucleotide chain length required to induce such interactions are presented, and the modification of RNA and DNA codewords, converting sense into missense or nonsense codewording, is suggested as a possible regulatory mechanism in protein synthesis.
Journal ArticleDOI
The separation of soluble ribonucleic acids on benzoylated diethylaminoethylcellulose.
Journal ArticleDOI
Tryptophan transfer RNA as the UGA suppressor.
TL;DR: It is concluded that UGA suppression is carried out by a tRNATrp whose anticodon-codon recognition is altered by a change elsewhere in the molecule.
Journal ArticleDOI
Separation of transfer ribonucleic acids by reverse phase chromatography.
TL;DR: Methods involving chemical treatment of specific t-RNAs have been reported and paper chromatographic procedures have produced partial resolutions of t-RNA.
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Natural Read-through at the UGA Termination Signal of Qβ Coat Protein Cistron
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