Book ChapterDOI
Translational and transcriptional control of protein synthesis during differentiation of dictyostelium discoideum
Harvey F. Lodish,Thomas H. Alton +1 more
- pp 253-272
TLDR
This chapter discusses translational and transcriptional control of protein synthesis during differentiation of Dictyostelium discoideum and gene expression during differentiation.Abstract:
Publisher Summary This chapter discusses translational and transcriptional control of protein synthesis during differentiation of Dictyostelium discoideum. To study the regulation of gene expression in a differentiating system such as Dictyostelium, one must identify genes whose expression is regulated. There are many examples of enzymic activities and surface antigens or proteins that appear or disappear at prescribed times of differentiation. However, in very few cases, it is completely clear whether the increase in activity is because of an increase in the rate of synthesis of the enzyme or antigen protein or to some other factor. The chapter also discusses gene expression during differentiation.read more
Citations
More filters
Journal ArticleDOI
The role of cyclic nucleotides and cell agglomeration in postaggregative enzyme synthesis in Dictyostelium discoideum.
Christopher D. Town,Julian Gross +1 more
TL;DR: It is concluded that the synthesis of the two postaggregative enzymes studied here follows immediately upon the phase of phosphodiesterase synthesis and that both phases of synthesis depend in some way upon elevation of intracellular cyclic nucleotide levels.
References
More filters
Journal ArticleDOI
High resolution two-dimensional electrophoresis of proteins.
TL;DR: This technique provides a method for estimation of the number of proteins made by any biological system and can resolve proteins differing in a single charge and consequently can be used in the analysis of in vivo modifications resulting in a change in charge.
Journal ArticleDOI
Three abundance classes in HeLa cell messenger RNA
TL;DR: Approximately 35,000 different poly(A)-containing RNA sequences are present in HeLa cell cytoplasm and the sequences are grouped in three distinct abundance classes.
Journal ArticleDOI
Translational Control of Protein Synthesis
TL;DR: A comparison of the rates of adoption and adoption of different approaches to translation of EUKARYOTIC mRNAs in the US and Europe over the past 50 years reveals a clear trend towards adoption of a more holistic approach.
Journal ArticleDOI
Model for the regulation of mRNA translation applied to haemoglobin synthesis.
TL;DR: A kinetic analysis of protein synthesis on ribosomes predicts that certain treatments which reduce the overall rate of polypeptide chain initiation wil inhibit translation preferentially of mRNAs with lower rate constants for polypeptic chain initiation.
Journal ArticleDOI
Dynamics of antigenic membrane sites relating to cell aggregation in Dictyostelium discoideum.
TL;DR: Using a quantitative technique for measuring cell association, two classes of target sites for blocking antibodies were distinguished and their developmental dynamics studied, indicating that in one cell, two independent classes of contact sites can be simultaneously active.
Related Papers (5)
Sequence elements that affect mRNA translational activity in developing Dictyostelium cells
Laura F. Steel,Allan Jacobson +1 more