K
Kathleen M. Carroll
Researcher at University of Manchester
Publications - 18
Citations - 1644
Kathleen M. Carroll is an academic researcher from University of Manchester. The author has contributed to research in topics: Quantitative proteomics & Polysome. The author has an hindex of 12, co-authored 18 publications receiving 1456 citations.
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Journal ArticleDOI
Development of a robust and repeatable UPLC-MS method for the long-term metabolomic study of human serum.
Eva Zelena,Warwick B. Dunn,David Broadhurst,Sue Francis-McIntyre,Kathleen M. Carroll,Paul Begley,Steve O'Hagan,Joshua Knowles,Antony Halsall,Ian D. Wilson,Douglas B. Kell +10 more
TL;DR: The observed drift in instrumental performance over time and its improvement with adjustment of the length of analytical block are described and allowed the authors to prepare SOPs for "fit for purpose" long-term UPLC-MS metabolomic studies, such as are being employed in the HUSERMET project.
Journal ArticleDOI
Global Translational Responses to Oxidative Stress Impact upon Multiple Levels of Protein Synthesis
Daniel Shenton,Julia B. Smirnova,Julian N. Selley,Kathleen M. Carroll,Simon J. Hubbard,Graham D. Pavitt,Mark P. Ashe,Chris M. Grant +7 more
TL;DR: In this paper, the authors analyzed the regulation of protein synthesis in response to oxidative stress induced by exposure to H2O2 in the yeast Saccharomyces cerevisiae.
Journal ArticleDOI
Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics
Marie Brown,Warwick B. Dunn,Paul D. Dobson,Yogendra Patel,Catherine L. Winder,Sue Francis-McIntyre,Paul Begley,Kathleen M. Carroll,David Broadhurst,Andy Tseng,Neil Swainston,Irena Spasic,Royston Goodacre,Douglas B. Kell +13 more
TL;DR: The combination of accurate mass data for a large collection of metabolites, theoretical isotope abundance data and knowledge of the different ion types detected provided a greater number of electrospray mass spectrometric signals which were putatively identified and with greater confidence in the samples studied.
Journal ArticleDOI
A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes.
Kieran Smallbone,Hanan L. Messiha,Kathleen M. Carroll,Catherine L. Winder,Naglis Malys,Naglis Malys,Warwick B. Dunn,Warwick B. Dunn,Ettore Murabito,Neil Swainston,Joseph O. Dada,Farid Khan,Pınar Pir,Evangelos Simeonidis,Irena Spasic,Irena Spasic,Jill A. Wishart,Dieter Weichart,Neil W. Hayes,Neil W. Hayes,Daniel Jameson,David S. Broomhead,Stephen G. Oliver,Stephen G. Oliver,Simon J. Gaskell,Simon J. Gaskell,John E.G. McCarthy,Norman W. Paton,Hans V. Westerhoff,Hans V. Westerhoff,Douglas B. Kell,Pedro Mendes,Pedro Mendes +32 more
TL;DR: This bottom‐up modelling study reveals that control over the metabolic network most directly involved in yeast glycolysis is more widely distributed than previously thought.
Journal ArticleDOI
Global Gene Expression Profiling Reveals Widespread yet Distinctive Translational Responses to Different Eukaryotic Translation Initiation Factor 2B-Targeting Stress Pathways
Julia B. Smirnova,Julian N. Selley,Fátima Sánchez-Cabo,Kathleen M. Carroll,A A Eddy,John E.G. McCarthy,Simon J. Hubbard,Graham D. Pavitt,Chris M. Grant,Mark P. Ashe +9 more
TL;DR: Yeast mRNAs are identified that are translationally maintained following either amino acid depletion or fusel alcohol addition, which demonstrate that these stress conditions elicit widespread yet distinct translational reprogramming, identifying a fundamental role for translational control in the adaptation to environmental stress.