Journal ArticleDOI
Treating menopause — MHT and beyond
Susan R. Davis,Rodney Baber +1 more
TLDR
Current available menopausal hormonal therapies and novel pharmaceutical alternatives to manage menopausal symptoms are discussed, with menopausal hormone therapy (MHT), including tibolone, remains the most effective treatment for menopausal Symptoms.About:
This article is published in Nature Reviews Endocrinology.The article was published on 2022-05-27. It has received 23 citations till now. The article focuses on the topics: Medicine & Menopause.read more
Citations
More filters
Journal ArticleDOI
Sex differences in musculoskeletal injury and disease risks across the lifespan: Are there unique subsets of females at higher risk than males for these conditions at distinct stages of the life cycle?
TL;DR: In this article , the authors discuss some of the relevant conditions associated with sex differences in risks for loss of MSK tissue integrity across the lifespan, and further discuss several of the implications of their variable relationship with sex hormones, their receptors and life events.
Journal ArticleDOI
Adipocyte Metabolism and Health after the Menopause: The Role of Exercise
TL;DR: In this paper , the loss of estrogen following the menopause eliminates protections against metabolic dysfunction, largely due to its role in the health and function of adipose tissue, while exercise has adipocyte-specific effects that may alleviate the adverse impact of estrogen loss through the menopausal transition period and beyond.
Journal ArticleDOI
Yin Huo Tang, a traditional Chinese herbal formula, relives ovariectomy and empty bottle stimulation-induced menopause-like symptoms in mice
TL;DR: Network pharmacology and molecular docking analyses revealed that the estrogen signaling pathway might play a key role in attenuating menopause-like symptoms and provided a rationale for using it as a potential therapeutic strategy.
Journal ArticleDOI
The effects of hormone replacement therapy on the microbiomes of postmenopausal women
TL;DR: In this article , a review discusses what is known about how the gut and vaginal microbiomes of postmenopausal women are responding to HRT, and the potential future of microbe-based therapeutics for symptoms of menopause.
Journal ArticleDOI
Coconut oil saturated fatty acids improved energy homeostasis but not blood pressure or cognition in VCD-treated female mice.
K. Sui,Ali Yasrebi,Candace R. Longoria,Avery T. MacDonell,Zehra H. Jaffri,Savannah A. Martinez,Samuel E Fisher,Natasha Malonza,Katie Jung,Kevin M. Tveter,Kimberly R. Wiersielis,Mehmet Uzumcu,Sue A. Shapses,Sara C. Campbell,Troy A. Roepke,Diana E. Roopchand +15 more
TL;DR: In this article , the authors used 4-vinylcyclohexene diepoxide (VCD)-treated mice to induce ovarian failure and estrogen deficiency combined with high fat-diet (HFD) feeding.
References
More filters
Journal ArticleDOI
Systematic Review: Process of Forming Academic Service Partnerships to Reform Clinical Education
TL;DR: This study’s findings can provide practical guidelines to steer partnership programs within the academic and clinical bodies, with the aim of providing a collaborative partnership approach to clinical education.
Journal ArticleDOI
Systematic review and meta-analysis
TL;DR: In this review the usual methods applied in systematic reviews and meta-analyses are outlined, and the most common procedures for combining studies with binary outcomes are described, illustrating how they can be done using Stata commands.
Journal ArticleDOI
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
Jacques E. Rossouw,Garnet L. Anderson,Ross L. Prentice,Andrea Z. LaCroix,Charles Kooperberg,Marcia L. Stefanick,Rebecca D. Jackson,Shirley A.A. Beresford,Barbara V. Howard,Karen C. Johnson,Jane Morley Kotchen,Judith K. Ockene +11 more
TL;DR: Overall health risks exceeded benefits from use of combined estrogen plus progestin for an average 5.2-year follow-up among healthy postmenopausal US women, and the results indicate that this regimen should not be initiated or continued for primary prevention of CHD.
Journal ArticleDOI
Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women
Stephen B. Hulley,Deborah Grady,Trudy L. Bush,Curt D Furberg,David M. Herrington,Betty Riggs,Eric Vittinghoff +6 more
TL;DR: Treatment with oral conjugated equine estrogen plus medroxyprogesterone acetate did not reduce the overall rate of CHD events in postmenopausal women with established coronary disease and the treatment did increase the rate of thromboembolic events and gallbladder disease.