Journal ArticleDOI
Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein Gi
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It is suggested that protein kinase C can elicit the phosphorylation and functional inactivation of α‐Gi in intact hepatocytes as pertussis toxin only causes the ADP‐ribosylation of the holomeric form of Gi, and it may be that phosphorylated leaves α‐ Gi in its holomersic state.About:
This article is published in FEBS Letters.The article was published on 1989-01-16. It has received 84 citations till now. The article focuses on the topics: Cyclase activity & Protein kinase A.read more
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'Crosstalk': a pivotal role for protein kinase C in modulating relationships between signal transduction pathways.
TL;DR: The very complexity of such systems, together with the need of the cell to monitor and respond to a variety of external stimuli, poses the question as to what overall controls are placed upon these various transduction mechanisms and how they might relate to each other.
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Modulation of Ca2+ channels by protein kinase C in rat central and peripheral neurons: Disruption of G protein-mediated inhibition
TL;DR: The results show that PKC regulates the inhibitory effects of G proteins, possibly by disrupting the coupling ofG proteins to Ca2+ channels.
Journal ArticleDOI
Protein Kinases, Protein Phosphorylation, and the Regulation of Insulin Secretion from Pancreatic β-Cells.
Peter B. Jones,Shanta J. Persaud +1 more
TL;DR: Protein Phosphatases and Protein Dephosphorylation in β-Cells and the Regulation of Insulin Secretion.
Journal ArticleDOI
The role of G proteins in transmembrane signalling.
TL;DR: This review will consider how different signalling mechanisms are adapted to the cellular processes they control by comparing the properties of the signalling pathways that involve G proteins with the simpler pathways that do not.
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Synergistic activation of the type I adenylyl cyclase by Ca2+ and Gs-coupled receptors in vivo.
TL;DR: Data illustrate that this adenylyl cyclase can couple Ca2+ and neurotransmitter signals to generate optimal cAMP levels, a property of the enzyme that may be important for its role in learning and memory in mammals.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
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G proteins: transducers of receptor-generated signals
TL;DR: This paper presents a meta-analysis of G Protein Interactions and its Foundations, which states that G Proteins are Law-Regulated and G Protein-Effector Interactions are Nonvolatile.
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Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase.
TL;DR: The results suggest that the alpha subunit of the inhibitory guanine-nucleotide-binding regulatory component of adenylate cyclase may be a physiological substrate for protein kinase C and that the function of the component in transducing inhibitory hormonal signals to adenYLate Cyclase is altered by its phosphorylation.
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Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.
TL;DR: It is found that in bovine cerebral cortex there are three proteins of similar molecular weight which are modified by pertussis toxin which differ in two functions: susceptibility to ADP-ribosylation and GTPase activity.