Journal ArticleDOI
Tributyltin stimulates apoptosis in rat thymocytes
TLDR
Results are consistent with a greater susceptibility of thymocytes to tributyltin and provide a basis for understanding its selective immunotoxicity in vivo.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 1990-11-15. It has received 179 citations till now. The article focuses on the topics: DNA fragmentation & Apoptosis.read more
Citations
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Journal ArticleDOI
Apoptosis: the biochemistry and molecular biology of programmed cell death.
TL;DR: This review first briefly covers some historical perspective on the discovery of apoptotic cell death, the characteristic morphology that accompanies this process, and the numerous cell types and mediators with which programmed cell death is associated.
Journal ArticleDOI
Ecotoxicology of organotin compounds.
TL;DR: The aquatic ecotoxicology of organotins is reviewed based on a multidisciplinary approach involving environmental chemical, toxicological, and ecological aspects, and the influence of speciation for bioavailability, basic modes of toxic action, and aquatic toxicity are discussed.
Journal ArticleDOI
The role of calcium in the regulation of apoptosis.
David J. McConkey,Sten Orrenius +1 more
TL;DR: This review will summarize what is known about the role of Ca2+ in the regulation of apoptosis and discuss howCa2+ might interact with some of the other biochemical signals implicated in cell death.
Journal Article
The role of calcium in the regulation of apoptosis.
TL;DR: A review of the role of Ca2+ in the regulation of apoptosis can be found in this paper, where the authors discuss how Ca2− might interact with some of the other biochemical signals implicated in cell death.
Journal ArticleDOI
Mitochondrial respiratory chain inhibitors induce apoptosis.
TL;DR: The specific mitochondrial respiratory chain inhibitors rotenone and antimycin A and the highly specific mitochondrial ATP‐synthase inhibitor oligomycin are shown to induce an apoptotic suicide response in cultured human lymphoblastoid and other mammalian cells within 12–18 h.
References
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Journal ArticleDOI
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid
TL;DR: The present study arose from the observation that a more intense colour was sometimes produced if, instead of being heated at 1000 for 10 min., the reaction mixture was allowed to stand overnight at room temperature.
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Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
TL;DR: It is shown here that this morphological change is closely associated with excision of nucleosome chains from nuclear chromatin, apparently through activation of an intracellular, but non-lysosomal, endonuclease.
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Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration
David J. McConkey,Pierluigi Nicotera,Pia Hartzell,Giorgio Bellomo,Andrew H. Wyllie,Sten Orrenius +5 more
TL;DR: The findings suggest that glucocorticoids induce thymocyte suicide through an elevation of cytosolic Ca2+ concentration resulting in endonuclease activation, DNA fragmentation, and cell death.
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Calcium-activated DNA fragmentation kills immature thymocytes.
TL;DR: The results suggest that thymocyte suicide is caused by extensive Ca2+‐stimulated DNA fragmentation, and the role of poly(ADP‐ribose) polymerase, an enzyme known to be activated by DNA damage, was assessed.
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2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation.
TL;DR: The results indicate that TCDD can kill immature thymocytes by initiating a suicide process similar to that previously described for glucocorticoid hormones.