Journal ArticleDOI
Über aktivierte Ester. III. Umsetzungen aktivierter Ester von Aminosäure‐ und Peptid‐Derivaten mit Aminen und Aminosäureestern
TLDR
A number of activated esters of amino acid and peptide derivatives were reacted with various organic amines, including amino acid esters, and good yields obtained, and the mild reaction conditions make it seem possible that the activated ester method of acylation may be of good use in peptide synthesis as discussed by the authors.Abstract:
A number of activated esters of amino acid and peptide derivatives were reacted with various organic amines, including amino acid esters. The good yields obtained, and the mild reaction conditions make it seem possible that the activated ester method of acylation may be of good use in peptide synthesis. Aminolysis by aromatic amines and by secondary amines proceeds only slowly, but the reaction can be greatly facilitated through the catalytic action of strong tertiary amines and of acids.read more
Citations
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Journal ArticleDOI
Peptide coupling reagents, more than a letter soup
TL;DR: Peptide Coupling Reagents, More than a Letter Soup Ayman El-Faham* and Fernando Albericio* Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028-Barcelona, Spain.
Book ChapterDOI
Synthesis and chemical properties of poly-alpha-amino acids.
Ephraim Katchalski,Michael Sela +1 more
TL;DR: The methods used to establish the chemical constitution of the polymers and their average molecular weights are given and the most suitable and commonly used are the N-carboxy-α-amino acid anhydrides.
Book ChapterDOI
Concept and early development of solid-phase peptide synthesis.
TL;DR: This new technique is proving to be of great practical importance in rapid drug discovery of peptide, peptide mimetic, and nonpeptide compounds, and active products with structures unpredictable from natural product sequences are being found in this way.
Journal ArticleDOI
Synthese von Peptid-Zwischenprodukten für den Aufbau eines corticotrop wirksamen Nonadecapeptids. I. Nϵ-t-Butyloxycarbonyl-L-lysin, Nϵ-(Nϵ-t-Butyloxycarbonyl-L-lysyl)-Nϵ-t-butyloxycarbonyl-L-lysin, Nϵ-t-Butyloxycarbonyl-L-lysyl-L-prolyl-L-valyl-glycin und Derivate
Robert Schwyzer,Werner Rittel +1 more
TL;DR: In this paper, a blocking group on Nϵ-t-butoxycarbonyl-L-lysine was synthesized and found to be a very versatile compound, it is readily removed by trifluoroacetic acid and by aqueous HCI.
Journal ArticleDOI
Discovery of Novel Myc−Max Heterodimer Disruptors with a Three-Dimensional Pharmacophore Model
Gabriela Mustata,Ariele Viacava Follis,Dalia I. Hammoudeh,Steven J. Metallo,Huabo Wang,Edward V. Prochownik,John S. Lazo,Ivet Bahar +7 more
TL;DR: These studies demonstrate the applicability of pharmacophore modeling to the identification of novel and potentially more puissant inhibitors of the c-Myc oncoprotein.
References
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Journal ArticleDOI
Une nouvelle méthode de synthèse peptidique
TL;DR: In this article, a solution contenant des anhydrides mixtes de la forme: ======@@@@@@@@@@@@@@@@¯¯¯¯@@@@@@@@@@@@@@@@@@@@@@@@▬▬▬▬▬▬▬======@@@@@@@@▬▬▬▬▬▬▬▬▬▬▬▬
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Ueber die Ester der Aminosäuren
TL;DR: Curtius as discussed by the authors wandte das gleiche Verfahren auf das Alanin, Leucin, Tyrosin, die Aminomalonsaure und die Asparaginsaure an, begnugte sich aber hier with der Isolierung der Hydrochlorate, welche ihm als Rohmaterial fur seine bekannten Studien uber aliphatische Diazoverbindungen dienten.
Journal ArticleDOI
The synthesis of cysteine-(cystine-) tyrosine peptides and the action thereon of crystalline pepsin.
Journal ArticleDOI
Über aktivierte Ester. II. Synthese aktivierter Ester von Aminosäure‐Derivaten
TL;DR: In this article, the synthesis of cristalline cyanomethyl esters and some other activated esters of amino acid and peptide derivatives are described. But the synthesisation of these esters is not discussed.
Journal ArticleDOI
Synthese von Polypeptiden. IX. Chloride der Aminosäuren und ihrer Acylderivate
TL;DR: In this paper, a new Methode für the Aufbau von Polypeptiden erwahnt, welche es gestattet, die Kette der Aminosauren auf der Seite des Carboxyls zu verlangern.