Journal ArticleDOI
Umbilical cord insertion into the lower segment of the uterus at 11 to 13 weeks' gestation is associated with maternal serum PAPP-A.
Junichi Hasegawa,Antonio Farina,Giuliana Simonazzi,Maria Bisulli,Chiara Puccetti,Gianluigi Pilu,Sandro Gabrielli,Nicola Rizzo +7 more
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TLDR
To evaluate whether the location of the placental cord insertion at 11 to 13 weeks' gestation affects the maternal serum pregnancy‐associated plasma protein‐A (PAPP‐A), a large number of mice were born with Down's syndrome.Abstract:
Objectives
To evaluate whether the location of the placental cord insertion (CI) at 11 to 13 weeks' gestation affects the maternal serum pregnancy-associated plasma protein-A (PAPP-A).
Methods
Cohort study was conducted in patients who underwent the first trimester screening including nuchal translucency and blood test. We additionally documented the CI site. The thickness of the placenta under the CI and the minimum distance on the uterine wall between the internal cervical os and the CI (Dis) were measured. The subjects were divided into two groups. Below the tenth percentile in multiples of median (MoM) of Dis were defined as cases in which CI was located on the lower uterine segment (low CI) and the others were defined as controls.
Results
A total of 117 subjects were analyzed. The thickness of the placenta (r = 0.237, p = 0.010) and Dis (r = 0.243, p = 0.008) was correlated with the crown-rump length (CRL). The maternal serum PAPP-A MoM in the low CI group was lower than in controls (0.76 ± 0.34 vs 1.16 ± 0.55; p = 0.009), whereas the other ultrasonographic measurements and maternal demographics were not different between the two groups.
Conclusion
CI on the lower segment of the uterus is associated with low maternal serum PAPP-A MoM levels. Copyright © 2011 John Wiley & Sons, Ltd.read more
Citations
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Journal ArticleDOI
Incidence of and risk indicators for vasa praevia: a systematic review
TL;DR: Vasa praevia (VP) is a rare phenomenon that is assumed to increase the risk of severe complications, including fetal death, and critical data on its incidence are lacking, so there is no rational basis for prenatal screening.
Journal ArticleDOI
Incidence of and Risk Indicators for Vasa Praevia: A Systematic Review
TL;DR: This dissertation aims to provide a history of web exceptionalism from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “Web 2.0” began to circulate.
Journal ArticleDOI
Assisted Reproductive Technique and Abnormal Cord Insertion: A Systematic Review and Meta-Analysis
Shinya Matsuzaki,Yutaka Ueda,Satoko Matsuzaki,Yoshikazu Nagase,Mamoru Kakuda,Misooja Lee,Michihide Maeda,Hiroki Kurahashi,Harue Hayashida,Tsuyoshi Hisa,Seiji Mabuchi,Shoji Kamiura +11 more
TL;DR: ART may be correlated with an increased prevalence of abnormal cord insertion, however, most studies could not exclude confounding factors; thus, further studies are warranted to characterize ART as a risk factor for ACI.
Journal ArticleDOI
The volume of the chorion villosum is associated with the location of the umbilical cord in the first trimester.
Masamitsu Nakamura,Junichi Hasegawa,Shoko Hamada,Ryu Matsuoka,Kiyotake Ichizuka,Akihiko Sekizawa,Takashi Okai +6 more
TL;DR: To clarify whether villous placental volumes in cases with low cord insertion (CI) are smaller than those with normal cord inserted (CI), a comparison study is performed on mice with and without low Cord insertion.
Journal ArticleDOI
The Characteristics and Obstetric Outcomes of Type II Vasa Previa: Systematic Review and Meta-Analysis
Shinya Matsuzaki,Yutaka Ueda,Satoko Matsuzaki,Mamoru Kakuda,Misooja Lee,Yuki Takemoto,Harue Hayashida,Michihide Maeda,Reisa Kakubari,Tsuyoshi Hisa,Seiji Mabuchi,Shoji Kamiura +11 more
TL;DR: In this paper , the authors examined the characteristics and obstetric outcomes of type II vasa previa, which is a rare fetal life-threatening obstetric disease classified into types I and II.
References
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Journal ArticleDOI
First-trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: A population-based screening study (The FASTER Trial)
Lorraine Dugoff,John C. Hobbins,Fergal D. Malone,T. Flint Porter,David A. Luthy,Christine H. Comstock,Gary D.V. Hankins,Richard L. Berkowitz,Irwin R. Merkatz,Sabrina D. Craigo,Ilan E. Timor-Tritsch,Steven R. Carr,Honor M. Wolfe,John Vidaver,Mary E. D'Alton +14 more
TL;DR: Low pregnancy-associated plasma protein A levels in the first trimester were associated strongly with a number of adverse pregnancy outcomes, and low free-beta subunit human chorionic gonadotropin levels and large nuchal translucency were both associated with early fetal loss.
Journal ArticleDOI
Early Pregnancy Levels of Pregnancy-Associated Plasma Protein A and the Risk of Intrauterine Growth Restriction, Premature Birth, Preeclampsia, and Stillbirth
Gordon C. S. Smith,Emily J. Stenhouse,Jennifer A. Crossley,David A. Aitken,Alan Cameron,J. Michael Connor +5 more
TL;DR: It is concluded that control of the IGF system in the first and early second trimester trophoblast may have a key role in determining subsequent pregnancy outcome.
Journal ArticleDOI
First-trimester screening for trisomy 21 by free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A: impact of maternal and pregnancy characteristics
TL;DR: To use multiple regression analysis to define the contribution of maternal variables that influence the measured concentration of free beta‐human chorionic gonadotropin and pregnancy‐associated plasma protein‐A, and the interaction between these covariates, in first‐trimester biochemical screening for trisomy 21.
Journal ArticleDOI
Association of extreme first-trimester free human chorionic gonadotropin-β, pregnancy-associated plasma protein A, and nuchal translucency with intrauterine growth restriction and other adverse pregnancy outcomes
David S. Krantz,Laura Goetzl,Joe Leigh Simpson,Elizabeth Thom,Julia Zachary,Terrence W. Hallahan,Richard K. Silver,Eugene Pergament,Lawrence D. Platt,Karen Filkins,Anthony Johnson,Maurice J. Mahoney,W. Allen Hogge,R. Douglas Wilson,Patrick Mohide,Douglas W. Hershey,Ronald J. Wapner +16 more
TL;DR: In this paper, the association between first-trimester trisomy 21 screening markers (free human chorionic gonadotropin-β [hCG], pregnancyassociated plasma protein A [PAPP-A], and nuchal translucency) and adverse pregnancy outcome was determined.
Journal ArticleDOI
Prenatal sonographic diagnosis of vasa previa: ultrasound findings and obstetric outcome in ten cases
TL;DR: To assess the specificity of sonographic diagnosis of vasa previa and pregnancy outcome in sonographically diagnosed cases, a large number of cases with known pregnancies are studied.