Journal ArticleDOI
Understanding juvenile myoclonic epilepsy: Contributions from neuroimaging
Joseph Anderson,Khalid Hamandi +1 more
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TLDR
Findings contribute to the ongoing debate surrounding the classification of epileptic syndromes, suggesting JME is a predominantly frontal thalamocortical network epilepsy, challenging the concept of a generalised epilepsy.About:
This article is published in Epilepsy Research.The article was published on 2011-05-01. It has received 54 citations till now. The article focuses on the topics: Myoclonic epilepsy & Juvenile myoclonic epilepsy.read more
Citations
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Journal ArticleDOI
Motor system hyperconnectivity in juvenile myoclonic epilepsy: a cognitive functional magnetic resonance imaging study.
Christian Vollmar,Jonathan O'Muircheartaigh,Gareth J. Barker,Mark R. Symms,Mark R. Symms,P. J. Thompson,P. J. Thompson,Veena Kumari,John S. Duncan,John S. Duncan,Dieter Janz,Mark P. Richardson,Matthias J. Koepp,Matthias J. Koepp +13 more
TL;DR: Coactivation in the motor cortex and supplementary motor area with increasing cognitive load and increased functional coupling between the motor system and cognitive networks provide an explanation how cognitive effort can cause myoclonic jerks in juvenileMyoclonic epilepsy.
Journal ArticleDOI
The neuropsychological and academic substrate of new/recent-onset epilepsies.
Daren C. Jackson,Kevin Dabbs,Natalie M. Walker,Jana E. Jones,David A. Hsu,Carl E. Stafstrom,Michael Seidenberg,Bruce P. Hermann +7 more
TL;DR: Children with new/recent-onset epilepsies exhibit considerable cognitive abnormality at baseline, including patterns of shared abnormalities across syndromes as well as unique syndrome-specific cognitive effects that are observed and sometimes exacerbated in specific IGE and ILRE syndrome.
Journal ArticleDOI
Altered thalamocortical functional connectivity in idiopathic generalized epilepsy
TL;DR: This work aimed to investigate alterations of thalamocortical functional network in patients with IGE using thalamic seed‐based functional connectivity (FC) analysis, and their relationships with frontal cognitive functions and clinical characteristics.
Journal ArticleDOI
Generalized Tonic-Clonic Seizures: Aberrant Interhemispheric Functional and Anatomical Connectivity
TL;DR: The bilateral anterior cingulate cortices may be important in the pathophysiology of generalized tonic-clonic seizures, and the connecting commissural fiber could be a target for future surgical treatment.
Journal ArticleDOI
Microstructural white matter abnormality and frontal cognitive dysfunctions in juvenile myoclonic epilepsy.
TL;DR: This study investigated changes of WM integrity in patients with JME, and their relationships with cognitive functions and epilepsy‐specific clinical factors.
References
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Journal ArticleDOI
Voxel-Based Morphometry—The Methods
John Ashburner,Karl J. Friston +1 more
TL;DR: In this paper, the authors describe the steps involved in VBM, with particular emphasis on segmenting gray matter from MR images with non-uniformity artifact and provide evaluations of the assumptions that underpin the method, including the accuracy of the segmentation and the assumptions made about the statistical distribution of the data.
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Revised Terminology and Concepts for Organization of Seizures and Epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005-2009
Anne T. Berg,Anne T. Berg,Samuel F. Berkovic,Martin J. Brodie,Jeffrey Buchhalter,J. Helen Cross,Walter van Emde Boas,Jerome Engel,Jacqueline A. French,Tracy A. Glauser,Gary W. Mathern,Solomon L. Moshé,Douglas R. Nordli,Perrine Plouin,Ingrid E. Scheffer +14 more
TL;DR: The International League Against Epilepsy (ILAE) Commission on Classification and Terminology has revised concepts, terminology, and approaches for classifying seizures and forms of epilepsy.
Book
Epilepsy : a comprehensive textbook
TL;DR: The neurobiology of epilepsy: neuronal excitability experimental modes of epilepsy and the autonomic nervous system comorbidity neuroendocrinology and the delivery of health care and socioeconomic issues.
Journal ArticleDOI
Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy
Patrick Cossette,Lidong Liu,Katéri Brisebois,Haiheng Dong,Haiheng Dong,Anne Lortie,Michel Vanasse,Jean-Marc Saint-Hilaire,Lionel Carmant,Andrei Verner,Wei-Yang Lu,Wei-Yang Lu,Yu Tian Wang,Guy A. Rouleau +13 more
TL;DR: It is reported that an Ala322Asp mutation in GABRA1, encoding the α1 subunit of the γ-aminobutyric acid receptor subtype A (GABAA), is found in affected individuals of a large French Canadian family with juvenile myoclonic epilepsy.
Journal ArticleDOI
Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain
Jean Gotman,Christophe Grova,Andrew P. Bagshaw,Eliane Kobayashi,Yahya Aghakhani,François Dubeau +5 more
TL;DR: Activations in thalamus and midfrontal regions confirm known involvement of these regions in the generation or spread of generalized epileptic discharges and suggest a brief lapse of responsiveness observed in patients during spike-and-wave discharges may result only from the epileptic discharge but also from its effect on normal brain function.