Journal ArticleDOI
Unstable genes unstable mind: beyond the central dogma of molecular biology
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TLDR
It is proposed that abnormally increased numbers of CAG repeats in many genes being expressed in the brain, coding for glutamine, cumulatively press for higher demand of glutamine in the respective brain cells, resulting in a metabolic crisis and dysregulation of the glutamate-glutamine cycle.About:
This article is published in Medical Hypotheses.The article was published on 2011-08-01. It has received 5 citations till now. The article focuses on the topics: Anticipation (genetics) & Psychosis.read more
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Journal ArticleDOI
Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease.
TL;DR: In this paper, the authors review aggregation mechanisms of proteins with expanded polyglutamine (polyQ)tracts, structural consequences of expanded polyQ ranging from monomers to fibrillar aggregates, the impact of protein context and posttranslational modifications on aggregation, and a potential role for lipid membranes in aggregation.
Book ChapterDOI
A Brief History of Triplet Repeat Diseases
TL;DR: A brief summary of progress with an emphasis on technical advances at different stages in understanding the mutations of repetitive DNA sequences within the genome is provided.
Journal ArticleDOI
Does the dopamine hypothesis explain schizophrenia
TL;DR: It is argued that the current model of aberrant salience explains psychosis in schizophrenia and provides a plausible linkage between the pharmacological and cognitive aspects of the disease.
Journal ArticleDOI
Mitochondrial dysfunction in psychiatric and neurological diseases: Cause(s), consequence(s), and implications of antioxidant therapy
TL;DR: An antioxidant therapeutic strategy for management of consequences of mitochondrial dysfunction in psychiatric and neurologic diseases is proposed and it is expected that this will not only reduces oxidative stress, but also promote anaerobic energy production.
Journal ArticleDOI
About epigenetics and the central dogma of molecular biology
TL;DR: This commentary on Myron Hofer's outstanding target article highlights several issues related to epigenetics and the central dogma of molecular biology.
References
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Journal ArticleDOI
Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies.
TL;DR: Despite evidence of heterogeneity across studies, meta-analytic results from 12 published twin studies of schizophrenia are consistent with a view of schizophrenia as a complex trait that results from genetic and environmental etiological influences.
Journal ArticleDOI
Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress.
Sudhakaran Prabakaran,Sudhakaran Prabakaran,J. E. Swatton,J. E. Swatton,Margaret Ryan,Margaret Ryan,S. J. Huffaker,S. J. Huffaker,Jeffrey T.-J. Huang,Jeffrey T.-J. Huang,Julian L. Griffin,Matthew T. Wayland,Tom C. Freeman,Frank Dudbridge,Kathryn S. Lilley,Natasha A. Karp,Svenja Hester,D. Tkachev,D. Tkachev,Michael L. Mimmack,Michael L. Mimmack,Robert H. Yolken,Maree J. Webster,E F Torrey,Sabine Bahn,Sabine Bahn +25 more
TL;DR: It is proposed that oxidative stress and the ensuing cellular adaptations are linked to the schizophrenia disease process and it is hoped that this new disease concept may advance the approach to treatment, diagnosis and disease prevention of schizophrenia and related syndromes.
Journal ArticleDOI
N-acetyl cysteine as a glutathione precursor for schizophrenia--a double-blind, randomized, placebo-controlled trial.
Michael Berk,David L. Copolov,David L. Copolov,Olivia M Dean,Olivia M Dean,Kristy Lu,Sue Jeavons,Ian Schapkaitz,Murray Anderson-Hunt,Fiona Judd,Fiona Katz,Paul Katz,Sean Ording-Jespersen,John Duncan Little,Philippe Conus,Michel Cuenod,Kim Q. Do,Ashley I. Bush,Ashley I. Bush,Ashley I. Bush +19 more
TL;DR: The data suggest that adjunctive NAC has potential as a safe and moderately effective augmentation strategy for chronic schizophrenia.