Journal ArticleDOI
Uptake and modification of 125I‐lipopolysaccharide by isolated rat Kupffer cells
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TLDR
The results indicate that Kupffer cells clear bacterial endotoxin in vitro and post‐uptake degradation occurs within 20 hr of incubation, inconsistent with a receptor‐mediated process as previously suggested.About:
This article is published in Hepatology.The article was published on 1988-11-01. It has received 25 citations till now. The article focuses on the topics: Incubation.read more
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Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock
TL;DR: The role of individual receptors such as the toll-like receptors and CD14 in the induction of proinflammatory cytokines and adhesion molecules is discussed in detail in this article, and the roles of other receptors that bind bacterial compounds such as scavenger receptors and their modulating role in inflammation are described.
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Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock
TL;DR: The role of individual receptors such as the toll-like receptors and CD14 in the induction of proinflammatory cytokines and adhesion molecules is discussed in detail and the therapies for the treatment of bacterial sepsis and septic shock are discussed in relation to the action of these receptors and proteins.
Journal ArticleDOI
The role of the liver in the response to LPS: experimental and clinical findings.
Emilio Jirillo,Domenico Caccavo,Thea Magrone,E Piccigallo,Luigi Amati,Annalisa Lembo,Christoph Kalis,Marina Gumenscheimer +7 more
TL;DR: In endotoxemic HCV-positive patients responsive to a combined treatment with IFN-alpha/ribavirin (RIB), endotoxemia was no longer detected at the end of the therapeutic regimen, and this may imply that an imbalance between T helper (Th)1 and Th2 derived cytokines could be envisaged in the non-responders.
Journal ArticleDOI
Involvement of tumor necrosis factor‐α in development of hepatic injury in galactosamine‐sensitized mice
Ieharu Hishinuma,Junichi Nagakawa,Kazuo Hirota,Kaname Miyamoto,Kazuo Tsukidate,Takashi Yamanaka,Kouichi Katayama,Isao Yamatsu +7 more
TL;DR: In this article, the authors showed that injection of lipopolysaccharide and D-galactosamine, at doses of 0.2 μg/kg and 800 mg/kg, respectively, elicited massive hepatic necrosis within 24 hr in C3H/HeN mice.
References
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Journal ArticleDOI
The preparation of 131i-labelled human growth hormone of high specific radioactivity
TL;DR: The loss of immunological reactivity at high specific radioactivities or at high levels of chemical substitution with STAI/sup 127/!iodine is demonstrated.
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Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion.
TL;DR: Isolated perfused rat livers were dispersed by a two-step procedure of Ca2+ removal (probably including the removal of a Ca2-dependent adhesion factor) followed by enzymatic treatment, and cells were active in the synthesis of RNA, protein, glycogen and various metabolites, and showed sensitivity towards steroid and polypeptide hormones.
Journal Article
The Clearance, Tissue Distribution, and Cellular Localization of Intravenously Injected Lipopolysaccharide in Rabbits
TL;DR: Results from SDS-PAGE of L PS recovered from plasma and liver homogenates indicated that no major cleavage of the glycolipid structure of LPS occurred within 180 min, and injected LPS is rapidly partitioned into tissuebound LPS and that remaining in plasma, neither of which shows evidence of major degradative change within 180 minutes.
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Endotoxin and bacteria in portal blood.
TL;DR: It is suggested that the Kupffer cells of the liver normally protect the systemic circulation from endotoxin, and that endotoxin is present in systemic blood only when liver function is impaired or gram-negative bacteremia is present.