scispace - formally typeset
Open AccessJournal ArticleDOI

Validation and validity of diagnoses in the General Practice Research Database: a systematic review

Reads0
Chats0
TLDR
The range of methods used to validate diagnoses in the General Practice Research Database (GPRD) are investigated, to summarize findings and to assess the quality of these validations.
Abstract
AIMS To investigate the range of methods used to validate diagnoses in the General Practice Research Database (GPRD), to summarize findings and to assess the quality of these validations. METHODS A systematic literature review was performed by searching PubMed and Embase for publications using GPRD data published between 1987 and April 2008. Additional publications were identified from conference proceedings, back issues of relevant journals, bibliographies of retrieved publications and relevant websites. Publications that reported attempts to validate disease diagnoses recorded in the GPRD were included. RESULTS We identified 212 publications, often validating more than one diagnosis. In total, 357 validations investigating 183 different diagnoses met our inclusion criteria. Of these, 303 (85%) utilized data from outside the GPRD to validate diagnoses. The remainder utilized only data recorded in the database. The median proportion of cases with a confirmed diagnosis was 89% (range 24-100%). Details of validation methods and results were often incomplete. CONCLUSIONS A number of methods have been used to assess validity. Overall, estimates of validity were high. However, the quality of reporting of the validations was often inadequate to permit a clear interpretation. Not all methods provided a quantitative estimate of validity and most methods considered only the positive predictive value of a set of diagnostic codes in a highly selected group of cases. We make recommendations for methodology and reporting to strengthen further the use of the GPRD in research.

read more

Content maybe subject to copyright    Report

Citations
More filters
Journal ArticleDOI

The effects of prescribing varenicline on two-year health outcomes: an observational cohort study using electronic medical records

TL;DR: Smokers prescribed varenicline in primary care in the United Kingdom do not appear to be less likely to die, be hospitalized or experience a myocardial infarction or chronic obstructive pulmonary disease during the following 2 years compared with smokers prescribed nicotine replacement therapy, but they gain more weight and attend primary care less frequently.
Journal ArticleDOI

Proton pump inhibitors and risk of all-cause and cause-specific mortality: A cohort study.

TL;DR: In this paper, the association between proton pump inhibitors (PPIs) and both all-cause and cause-specific mortality was investigated using propensity score (PS) weighted Cox models.
Journal ArticleDOI

Quality and Completeness of Myocardial Infarction Recording in Clinical Practice Research Datalink Aurum.

TL;DR: In this article, the authors examined data source agreement of myocardial infarction (MI) diagnoses recorded in the Clinical Practice Research Datalink (CPRD) Aurum database compared with linked Hospital Episode Statistics (HES) data.
Journal ArticleDOI

Evaluation of the epidemiology of peanut allergy in the United Kingdom.

TL;DR: The prevalence and incidence of PA increased markedly over the study period and was associated with atopic conditions and anaphylaxis, and PA patients had increased adrenaline prescriptions.
References
More filters
Journal ArticleDOI

Epidemiology of fractures in England and Wales

TL;DR: Varying patterns of fracture incidence were observed with increasing age; whereas some fractures became more common in later life (vertebral, distal forearm, hip, proximal humerus, rib, clavicle, pelvis), others were more frequent in childhood and young adulthood.
Journal ArticleDOI

Validation of information recorded on general practitioner based computerised data resource in the United Kingdom.

TL;DR: Clinical information available on the computer records of the general practitioners who participated in this study is satisfactory for many clinical studies.
Journal ArticleDOI

Validity of the general practice research database.

TL;DR: The quality and completeness of the data that the GPRD contains are evaluated with extensive experience with this automated database.
Journal ArticleDOI

The general practice research database: role in pharmacovigilance.

TL;DR: An update of recent developments to the GPRD and new data available from it — including spontaneously recorded suspected adverse drug reactions — is presented, with a description of how the data can be used to support a variety of pharmacovigilance applications.
Journal ArticleDOI

Recent trends in physician diagnosed COPD in women and men in the UK

TL;DR: While prevalence rates of COPD in the UK seem to have peaked in men, they are continuing to rise in women, and this trend, together with the ageing of the population and the long term cumulative effect of pack-years of smoking in women is likely to increase the present burden of COPd in theUK.
Related Papers (5)