Journal ArticleDOI
Variation of Ciliary Beat Pattern in Three Different Beating Planes in Healthy Subjects.
TLDR
This study demonstrates a lack of uniformity and consistency in manual CBP analysis of samples from healthy subjects, emphasizing the risk of automated CBF analysis in limited regions of interest and of single and limited manualCBP analysis.About:
This article is published in Chest.The article was published on 2017-05-01. It has received 30 citations till now. The article focuses on the topics: Ciliary dyskinesia.read more
Citations
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Journal ArticleDOI
Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline
Adam J. Shapiro,Stephanie D. Davis,Deepika Polineni,Michele Manion,Margaret Rosenfeld,Sharon D. Dell,Mark A. Chilvers,Thomas W. Ferkol,Maimoona A. Zariwala,Scott D. Sagel,Maureen B. Josephson,Lucy Morgan,Ozge Yilmaz,Kenneth N. Olivier,Carlos Milla,Jessica E. Pittman,M. Leigh Anne Daniels,Marcus Herbert Jones,Ibrahim A. Janahi,Stephanie M. Ware,Sam J. Daniel,Matthew L. Cooper,Lawrence M. Nogee,Billy Anton,Tori Eastvold,Lynn Ehrne,Elena Guadagno,Michael R. Knowles,Margaret W. Leigh,Valery Lavergne +29 more
TL;DR: This document presents the American Thoracic Society clinical practice guidelines for the diagnosis of primary ciliary dyskinesia (PCD) and made recommendations for or against the use of specific diagnostic tests as compared with using the current reference standard (transmission electron microscopy and/or genetic testing) for the diagnoses of PCD.
Journal ArticleDOI
Accuracy of High-Speed Video Analysis to Diagnose Primary Ciliary Dyskinesia.
Bruna Rubbo,Amelia Shoemark,Claire L. Jackson,Robert A. Hirst,James Thompson,Joseph Hayes,Emily Frost,Fiona Copeland,Claire Hogg,Christopher O'Callaghan,Isabel C. Reading,Jane S. Lucas,Jane S. Lucas +12 more
TL;DR: HSVA can be reliably used to counsel patients and commence treatment on the day of testing while awaiting confirmatory investigations, and has high interobserver agreement for “PCD‐positive” outcomes.
Journal ArticleDOI
Diagnosis of primary ciliary dyskinesia.
TL;DR: The respiratory signs and symptoms of primary ciliary dyskinesia, as well as the screening tests for and diagnostic investigation of the disease, together with details related to ciliary function, ciliary ultrastructure, and genetic studies are reviewed.
Journal ArticleDOI
Quantifying Ciliary Dynamics during Assembly Reveals Stepwise Waveform Maturation in Airway Cells.
TL;DR: Analyzing ciliary motion by high‐speed video microscopy of ciliated cells sampled from human lung airways compared with primary culture cells that undergo ciliogenesis in vitro suggests that the stepwise variation in waveform development is dependent on cilia length and potentially on outer dynein arm assembly.
Journal ArticleDOI
Accuracy of Nasal Nitric Oxide Measurement as a Diagnostic Test for Primary Ciliary Dyskinesia. A Systematic Review and Meta-analysis
Adam J. Shapiro,Maureen B. Josephson,Margaret Rosenfeld,Ozge Yilmaz,Stephanie D. Davis,Deepika Polineni,Elena Guadagno,Margaret W Leigh,Valery Lavergne +8 more
TL;DR: In this paper, the authors performed a systematic review to assess the utility of nNO measurement (index test) as a diagnostic tool compared with the reference standard of electron microscopy (EM) evaluation of ciliary defects and/or detection of biallelic mutations in PCD genes.
References
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Journal ArticleDOI
Primary Ciliary Dyskinesia. Recent Advances in Diagnostics, Genetics, and Characterization of Clinical Disease
TL;DR: The prevalence of primary ciliary dyskinesia (PCD) is difficult to determine, primarily because of limitations in diagnostic methods that focus on testing ciliary ultrastructure and function as mentioned in this paper.
Journal ArticleDOI
Regulation of mammalian ciliary beating.
TL;DR: The regulation mechanisms of ciliary beat regulation by intracellular second messengers remain somewhat controversial, favoring an immediate, direct action of calcium on ciliary beating and a second cyclic nucleotide-dependent phase.
Journal ArticleDOI
Mutations in radial spoke head protein genes RSPH9 and RSPH4A cause primary ciliary dyskinesia with central-microtubular-pair abnormalities
Victoria H. Castleman,Leila Romio,Rahul Chodhari,Robert A. Hirst,Sandra C. P. De Castro,Keith A. Parker,Patricia Ybot-Gonzalez,Richard D. Emes,Stephen W. Wilson,Colin Wallis,Colin A. Johnson,Rene J. Herrera,Andrew Rutman,Mellisa Dixon,Amelia Shoemark,Andrew Bush,Claire Hogg,R. Mark Gardiner,Orit Reish,Nicholas D. E. Greene,Christopher O'Callaghan,Saul Purton,Eddie M.K. Chung,Hannah M. Mitchison +23 more
TL;DR: Investigation of the effect of knockdown or mutations of RSPH9 orthologs in zebrafish and Chlamydomonas indicate that radial spoke head proteins are important in maintaining normal movement in motile, "9+2"-structure cilia and flagella.
Journal ArticleDOI
Ciliary beat pattern is associated with specific ultrastructural defects in primary ciliary dyskinesia.
TL;DR: This data indicates that different ultrastructural defects responsible for PCD result in predictable beat patterns, which might help in the diagnostic evaluation of patients suspected of having PCD.
Journal ArticleDOI
Analysis of ciliary beat pattern and beat frequency using digital high speed imaging: comparison with the photomultiplier and photodiode methods
TL;DR: Respiratory cilia beat forwards and backwards within the same plane without a classical sideways recovery sweep and both ciliary beat frequency and beat pattern were evaluated.
Related Papers (5)
European Respiratory Society guidelines for the diagnosis of primary ciliary dyskinesia.
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