Journal ArticleDOI
Vitamin D receptor gene polymorphism, bone mass, body size, and vitamin D receptor density
TLDR
Bone mineral content (BMC) at both spine and total body was significantly associated with VDR gene alleles, and a similar association was noted between allele and body size variables, particularly weight.Abstract:
We determined vitamin D receptor (VDR) gene alleles (based on the BsmI restriction site polymorphism), duodenal mucosal receptor density, bone mass at spine and total body, and body size in 32 healthy premenopausal females. While we found no relationship between allele and receptor density in duodenal mucosa, bone mineral content (BMC) at both spine and total body was significantly associated with VDR gene alleles. BMC was highest for the bb allele, lowest for BB, and intermediate for Bb. A similar association was noted between allele and body size variables, particularly weight. When BMC was adjusted for body weight, the association with VDR polymorphism disappeared. The VDR gene polymorphism may be affecting bone mass not through classical nutritional mechanisms (e.g., intestinal calcium absorption), but through an influence on body size.read more
Citations
More filters
Journal ArticleDOI
The nuclear vitamin D receptor: biological and molecular regulatory properties revealed.
Mark R. Haussler,G. K. Whitfield,Carol A. Haussler,J. C. Hsieh,Paul Thompson,S. H. Selznick,Carlos Encinas Dominguez,Peter W. Jurutka +7 more
TL;DR: The scope of this review will be limited to highlighting the actions of 1,25(OH)2D3 mediated by nuclear VDR and discussing new developments in the structure/function analysis of the receptor, including the phenotype of VDR knockout mice and the biochemical classification of patients with point mutations in the receptor.
Journal ArticleDOI
Genetics of Osteoporosis
TL;DR: Find the susceptibility genes underlying osteoporosis requires identifying specific alleles that coinherit with key heritable phenotypes in bone strength, and identification of the genes underlying bone strength in mammals such as the mouse is likely to be of major assistance in human studies.
Journal ArticleDOI
Are vitamin D receptor polymorphisms associated with bone mineral density? A meta‐analysis
Glinda S. Cooper,David M. Umbach +1 more
TL;DR: VDR polymorphisms represent one genetic factor affecting BMD, but further research into the mechanisms, clinical significance, and its relation between other genetic and environmental factors is needed.
Journal ArticleDOI
Role of calcium and dairy products in energy partitioning and weight management
TL;DR: It is confirmed by epidemiologic data and recent clinical trials, which indicate that diets that include > or =3 daily servings of dairy products result in significant reductions in adipose tissue mass in obese humans in the absence of caloric restriction and markedly accelerate weight and body fat loss secondary to caloric restriction compared with diets low in dairy products.
Journal ArticleDOI
Genetics of osteoporosis.
TL;DR: This work focuses on Vitamin D Receptor (VDR) gene polymorphisms and bone phenotype, and potential mechanisms for VDR allelic associations.
References
More filters
Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
Journal ArticleDOI
Prediction of Bone-Density from Vitamin-D Receptor Alleles
Nigel Alexander Morrison,Jian Cheng Qi,Akifumi Tokita,Paul J. Kelly,Linda Crofts,Tuan V. Nguyen,Philip N. Sambrook,John A. Eisman +7 more
TL;DR: It is shown that common allelic variants in the gene encoding the vitamin D receptor can be used to predict differences in bone density, accounting for up to 75% of the total genetic effect on bone density in healthy individuals.
Journal ArticleDOI
Bone mineral density in relation to polymorphism at the vitamin D receptor gene locus.
TL;DR: There was no relationship between genotype for any of the three polymorphisms and BMD at any skeletal site in the twin population, considered either as a total population, both with and without twins discordant for age at menopause or use of estrogen, or as a premenopausal population.
Journal ArticleDOI
An investigation of sources of variation in calcium absorption efficiency.
TL;DR: Serum 25OHD, mouth to cecum transit time, and fasting urinary calcium/creatinine ratio explained 44% of the observed variation in calcium absorption efficiency, suggesting that 25O HD plays a more prominent role in the regulation of calcium absorption than is generally believed.
Related Papers (5)
Are vitamin D receptor polymorphisms associated with bone mineral density? A meta‐analysis
Glinda S. Cooper,David M. Umbach +1 more