Vitamin D status as a determinant of peak bone mass in young Finnish men.
Ville-Valtteri Välimäki,Henrik Alfthan,Eero Lehmuskallio,Eliisa Löyttyniemi,Timo Sahi,Ulf-Håkan Stenman,Harri Suominen,Harri Suominen,Matti Välimäki +8 more
TLDR
Vitamin D deficiency is very common in Finnish young men in the winter, and it may have detrimental effects on the acquisition of maximal peak bone mass, as well as prophylaxis for osteoporosis.Abstract:
Severe vitamin D deficiency causes rickets, but scarce data are available about the extent to which vitamin D status determines the development of the peak bone mass in young adults. Our aim was to evaluate the prevalence of vitamin D deficiency [serum 25-hydroxyvitamin D (25-OHD) less than the lower limit of the reference range of 20-105 nmol/liter] and the relationship between vitamin D status and peak bone mass among young Finnish men. A cross-sectional study of determinants of peak bone mass with data on lifestyle factors collected retrospectively was performed in 220 young men, aged 18.3-20.6 yr. One hundred and seventy men were recruits of the Finnish Army, and 50 were men of similar age who had postponed their military service for reasons not related to health. Bone mineral content, bone mineral density, and scan area were measured in lumbar spine and upper femur by dual energy x-ray absorptiometry. Serum 25-OHD concentrations were followed prospectively for 1 yr. In July 2000, only 0.9% of the men had vitamin D deficiency, but 6 months later, in the winter, the respective percentage was 38.9%. After adjusting for age, height, weight, exercise, smoking, calcium, and alcohol intake, there existed a positive correlation between serum 25-OHD and bone mineral content at lumbar spine (P = 0.057), femoral neck (P = 0.041), trochanter (P = 0.010), and total hip (P = 0.025). The correlation coefficients for the bone mineral densities at the four measurement sites were 0.035, 0.061, 0.056, and 0.068, respectively. No correlation was found to scan area. We conclude that vitamin D deficiency is very common in Finnish young men in the winter, and it may have detrimental effects on the acquisition of maximal peak bone mass. As in Finland vitamin D supplementation to infants is now stopped at the age of 3 yr, it can be asked whether at our latitude it should be continued from that age onward, not for the prevention of rickets, but as prophylaxis for osteoporosis.read more
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Effectiveness and safety of vitamin D in relation to bone health.
Ann Cranney,Tanya Horsley,Siobhan O'Donnell,Hope A. Weiler,Lorri Puil,Daylily S. Ooi,Stephanie A. Atkinson,Leanne M Ward,David Moher,David A. Hanley,Manchung Fang,Fatemeh Yazdi,Chantelle Garritty,Margaret Sampson,Nick Barrowman,Alex Tsertsvadze,Vasil Mamaladze +16 more
TL;DR: The largest body of evidence on vitamin D status and bone health was in older adults with a lack of studies in premenopausal women and infants, children and adolescents, and there was fair evidence of an association between low circulating 25(OH)D concentrations and established rickets.
Journal Article
Benefits and requirements of vitamin D for optimal health: a review.
TL;DR: The consensus of scientific understanding appears to be that vitamin D deficiency is reached for serum 25-hydroxyvitamin D (25OHD) levels less than 20 ng/mL (50 nmol/L), insufficiency in the range from 20-32 ng/ mL, and sufficiency in therange from 33-80 ng/RL, with normal in sunny countries 54-90 ng/L, and excess greater than 100 ng/ML.
Journal ArticleDOI
An association of serum vitamin D concentrations < 40 nmol/L with acute respiratory tract infection in young Finnish men
Ilkka Laaksi,Juha-Petri Ruohola,Pentti Tuohimaa,Anssi Auvinen,Riina Haataja,Harri Pihlajamäki,Timo Ylikomi +6 more
TL;DR: Clinical trials of vitamin D supplementation are needed to investigate whether it enhances immunity to microbial infection in young Finnish men.
Journal ArticleDOI
Vitamin D–binding protein modifies the vitamin D–bone mineral density relationship
Camille E. Powe,Catherine Ricciardi,Anders H. Berg,Delger Erdenesanaa,Gina Collerone,Elizabeth Ankers,Julia Wenger,S. Ananth Karumanchi,Ravi Thadhani,Ishir Bhan +9 more
TL;DR: The findings have important implications for vitamin D supplementation in vitamin D–deficient states and future studies should continue to explore the relationship between free and bioavailable 25(OH)D and health outcomes.
Journal ArticleDOI
Osteoporosis: the role of micronutrients
TL;DR: Healthcare professionals need to be aware of the importance of adequate calcium and vitamin D intakes (easily monitored by serum 25(OH)D) for optimal bone health, as well as the prevention of falls and fractures.
References
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Journal ArticleDOI
Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study
Elina Hyppönen,Esa Läärä,Antti Reunanen,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Suvi M. Virtanen +5 more
TL;DR: Vitamin D supplementation was associated with a decreased frequency of type 1 diabetes when adjusted for neonatal, anthropometric, and social characteristics and Ensuring adequate vitamin D supplementation for infants could help to reverse the increasing trend in the incidence ofType 1 diabetes.
Journal ArticleDOI
Prevalence of Vitamin D Insufficiency in an Adult Normal Population
Marie-Claire Chapuy,Paul Preziosi,M. Maamer,S. Arnaud,Pilar Galan,Serge Hercberg,P. J. Meunier +6 more
TL;DR: The results showed that in French normal adults living in an urban environment with a lack of direct exposure to sunshine, diet failed to provide an adequate amount of vitamin D, and the clinical utility of winter supplementation with low doses ofitamin D was discussed.
Journal ArticleDOI
Hypovitaminosis D in Medical Inpatients
Melissa K. Thomas,Donald M. Lloyd-Jones,Ravi Thadhani,Albert C. Shaw,Donald J. Deraska,Barrett T. Kitch,Eleftherios C. Vamvakas,Ian M. Dick,Richard L. Prince,Joel S. Finkelstein +9 more
TL;DR: Hypovitaminosis D is common in general medical inpatients, including those with vitamin D intakes exceeding the recommended daily allowance and those without apparent risk factors for vitamin D deficiency.
Journal ArticleDOI
Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial.
TL;DR: Four monthly supplementation with 100 000 IU oral vitamin D may prevent fractures without adverse effects in men and women living in the general community.
Journal ArticleDOI
Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence.
TL;DR: It is indicated that during pubertal development, major differences are observed in bone mass growth according to sex and skeletal site, suggesting that the generally accepted notion that in both males and females bone mass continues to substantially accumulate at all skeletal sites until the fourth decade may not be a constant in human physiology.