Journal ArticleDOI
Vitamin E supplementation in chronically hemodialyzed patients - influence on blood hemoglobin and plasma (anti)oxidant status.
TLDR
When treated with ESA and iron on a long-term basis, the response to the vitamin E supplementation in chronically hemodialyzed patients is largely dependent on their basal blood hemoglobin and serum vitamin E concentrations.Abstract:
Background: Disturbed oxidant/antioxidant status is involved in pathogenesis of anemia in end stage renal disease. There is evidence that vitamin E supplementation can increase blood hemoglobin in chronically hemodialyzed patients. However, the interindividual variation in response to the supplementation has not been fully addressed. Methods: 24 chronically hemodialyzed patients were supplemented with vitamin E (400 IU/day) in a period of two months. They had already been treated with erythropoiesis stimulating agents (ESA) and iron on a long-term basis, which was continued during the study period. A group of 20 healthy volunteers served as control subjects. Complete blood count, general biochemistry assays, the redox status by total thiols, oxidative stress by reactive oxygen metabolites, antioxidant status by biological antioxidant potential, and vitamin E (α- and γ- tocopherol) were measured before the start of supplementation, one month and two months later. Results: Overall, the vitamin E supplementation did not cause an increase of blood hemoglobin, hematocrit or red blood cells. However, 50 % of the patients with basal blood hemoglobin below 12.0 g/dL (N = 10) responded to the supplementation with its continuous increase. In addition, vitamin E exhibited a slight prooxidant effect only in the subgroup of patients with basal blood hemoglobin of ≥ 12.0 g/dL, two months after the start of supplementation (decreased total thiols: 300 ± 31 vs. 277 ± 36 µmol/L, p 0.05; decreased biological antioxidant potential: 2278 ± 150 vs. 2171 ± 126 µEq/L, p < 0.025), which coincided with their significantly increased serum α-tocopherol concentrations in comparison to the patients with basal blood hemoglobin below 12.0 g/dL (41.3 ± 7.2 vs. 59.9 ± 19.2 µmol/L, p < 0.025). Conclusions: When treated with ESA and iron on a long-term basis, the response to the vitamin E supplementation in chronically hemodialyzed patients is largely dependent on their basal blood hemoglobin and serum vitamin E concentrations.read more
Citations
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Polyphenols in human nutrition: from the in vitro antioxidant capacity to the beneficial effects on cardiometabolic health and related inter-individual variability - an overview and perspective.
TL;DR: The phenomenon of inter-individual variability in response to consumption of polyphenols is of relevance for supplementation with antioxidant (pro)vitamins and will potentially lead to personalised dietary recommendations.
Journal ArticleDOI
Circadian rhythm and time-of-day-effects of (anti)oxidant biomarkers for epidemiological studies.
TL;DR: Diurnal variations in some of the studied biomarkers of oxidative stress, redox and antioxidant status in serum/plasma should be taken into account when designing and conducting clinical and epidemiological studies.
References
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Journal ArticleDOI
Kidney Disease: Improving Global Outcomes guidelines on anaemia management in chronic kidney disease: a European Renal Best Practice position statement
Francesco Locatelli,Peter Bárány,Adrian Covic,Angel L.M. de Francisco,Lucia Del Vecchio,David Goldsmith,Walter H. Hörl,Gérard M. London,Raymond Vanholder,Wim Van Biesen +9 more
TL;DR: The group concentrated only on those guidelines which the group considered worth amending or adapting, and all guidelines not specifically mentioned are fully endorsed.
Journal ArticleDOI
Antioxidant and prooxidant activity of (alpha)-tocopherol in human plasma and low density lipoprotein
TL;DR: The results indicate that the level of oxidative stress and concentration of co-antioxidants, such as ascorbate, capable of regenerating alpha-tocopherol in the oxidizing lipoprotein particle, appear to represent major factors determining alpha-ocopherol activity towards oxidation both in human plasma and LDL.
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Meta-Regression Analyses, Meta-Analyses, and Trial Sequential Analyses of the Effects of Supplementation with Beta-Carotene, Vitamin A, and Vitamin E Singly or in Different Combinations on All-Cause Mortality: Do We Have Evidence for Lack of Harm?
TL;DR: Beta-carotene and vitamin E in doses higher than the RDA seem to significantly increase mortality, whereas the authors lack information on vitamin A.
Journal ArticleDOI
Suicidal erythrocyte death in end-stage renal disease
Majed Abed,Ferruh Artunc,Kousi Alzoubi,Sabina Honisch,Dorothea Baumann,Michael Föller,Florian Lang +6 more
TL;DR: Both, dialyzable components of uremic plasma and dialysis procedure, trigger eryptosis at least in part by increasing erythrocyte [Ca2+]i, ROS, and ceramide formation.
Journal ArticleDOI
Antioxidants for chronic kidney disease
Min Jun,Vinod Venkataraman,Mona Razavian,Bruce A. Cooper,Sophia Zoungas,Toshiharu Ninomiya,Angela C Webster,Vlado Perkovic +7 more
TL;DR: Antioxidant therapy was found to significantly reduce development of end-stage of kidney disease (ESKD) and lower serum creatinine levels and there was significant heterogeneity for cardiovascular disease when studies were analysed by CKD stage.