Journal ArticleDOI
Voluntary ethanol intake in the rat and the associated accumbal dopamine overflow are blocked by ventral tegmental mecamylamine
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The present results indicate that nicotinic acetylcholine receptors in the ventral tegmental area are involved in the positive reinforcing effects of ethanol and could represent a new pharmacological treatment principle against alcohol abuse.About:
This article is published in European Journal of Pharmacology.The article was published on 1998-10-09. It has received 200 citations till now. The article focuses on the topics: Mecamylamine & Ventral tegmental area.read more
Citations
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Journal ArticleDOI
Alcoholism: a systems approach from molecular physiology to addictive behavior.
TL;DR: This review adheres to a systems biology perspective such that the interaction of alcohol with primary and secondary targets within the brain is described in relation to the behavioral consequences.
Journal ArticleDOI
Neuropharmacology of alcohol addiction.
TL;DR: The activity of the mesolimbic dopaminergic system plays a crucial role during the initiation phase of alcohol consumption and the neurochemical substrates that are involved in the initiation and maintenance phase of an alcohol drinking behaviour are discussed.
Journal ArticleDOI
Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens.
Elisabet Jerlhag,Emil Egecioglu,Suzanne L. Dickson,Annika Douhan,Lennart Svensson,Jörgen A. Engel +5 more
TL;DR: Findings indicate that ghrelin might, via activation of GHSR‐1A in the VTA and LDTg, stimulate the acetylcholine–dopamine reward link, implicating that gh Relin is a part of the neurochemical overlap between the reward systems and those that regulate energy balance.
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Varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking
TL;DR: The selectivity of varenicline in decreasing ethanol consumption combined with its reported safety profile and mild side effects in humans suggest that varenICline may prove to be a treatment for alcohol dependence.
Journal ArticleDOI
Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: implications for its involvement in brain reward.
Elisabet Jerlhag,Emil Egecioglu,Suzanne L. Dickson,Malin E. Andersson,Lennart Svensson,Jörgen A. Engel +5 more
TL;DR: Ghrelin may, via activation of the acetylcholine–dopamine reward link, increase the incentive values of signals associated with motivated behaviours of importance for survival such as feeding behaviour, and whether this has therapeutic implications for compulsive addictive behaviours.
References
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The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
A Neural Substrate of Prediction and Reward
TL;DR: Findings in this work indicate that dopaminergic neurons in the primate whose fluctuating output apparently signals changes or errors in the predictions of future salient and rewarding events can be understood through quantitative theories of adaptive optimizing control.
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The neural basis of drug craving: An incentive-sensitization theory of addiction
TL;DR: S sensitization of incentive salience can produce addictive behavior even if the expectation of drug pleasure or the aversive properties of withdrawal are diminished and even in the face of strong disincentives, including the loss of reputation, job, home and family.
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A psychomotor stimulant theory of addiction
Roy A. Wise,Michael A. Bozarth +1 more
TL;DR: A new attempt at a general theory of addiction is offered, based on the common denominator of the psychomotor stimulants---amphetamine, cocaine, and related drugs---rather than on thecommon denominators of the socalled depressant drugs~opiates, barbiturates, alcohol, and others.
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Drugs of abuse: anatomy, pharmacology and function of reward pathways
TL;DR: The results suggest that brain reward systems have a multidetermined neuropharmacological basis that may involve some common neuroanatomical elements.