Wavefront sensorless adaptive optics ophthalmoscopy in the human eye
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TLDR
Real-time (25 Hz), wavefront sensorless adaptive optics imaging in the living human eye with image quality rivaling that of wave front sensor based control in the same system is demonstrated.Abstract:
Wavefront sensor noise and fidelity place a fundamental limit on achievable image quality in current adaptive optics ophthalmoscopes. Additionally, the wavefront sensor ‘beacon’ can interfere with visual experiments. We demonstrate real-time (25 Hz), wavefront sensorless adaptive optics imaging in the living human eye with image quality rivaling that of wavefront sensor based control in the same system. A stochastic parallel gradient descent algorithm directly optimized the mean intensity in retinal image frames acquired with a confocal adaptive optics scanning laser ophthalmoscope (AOSLO). When imaging through natural, undilated pupils, both control methods resulted in comparable mean image intensities. However, when imaging through dilated pupils, image intensity was generally higher following wavefront sensor-based control. Despite the typically reduced intensity, image contrast was higher, on average, with sensorless control. Wavefront sensorless control is a viable option for imaging the living human eye and future refinements of this technique may result in even greater optical gains.read more
Citations
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Proceedings ArticleDOI
Adaptive optics in microscopy
TL;DR: Applications of adaptive optics in the related areas of optical data storage, optical tweezers and micro/nanofabrication are reviewed, particularly in confocal and two-photon microscopes.
Journal ArticleDOI
Adaptive optics ophthalmoscopy
Austin Roorda,Jacque L. Duncan +1 more
TL;DR: This review starts with a brief history and description of adaptive optics (AO) technology, followed by a showcase of the latest capabilities of AO systems for imaging the human retina and an extensive review of the literature on where AO is being used clinically.
Journal ArticleDOI
Adaptive optics imaging of the human retina.
TL;DR: Human AO retinal imaging is examined with a concentration on the use of the Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO), which holds promise for being incorporated into clinical trials providing cell specific approaches to monitoring diseases and therapeutic interventions.
Journal ArticleDOI
Vision science and adaptive optics, the state of the field.
Susana Marcos,John S. Werner,Stephen A. Burns,William H. Merigan,Pablo Artal,David A. Atchison,Karen M. Hampson,Richard Legras,Linda Lundström,Geungyoung Yoon,Joseph Carroll,Stacey S. Choi,Nathan Doble,Adam M. Dubis,Alfredo Dubra,Ann E. Elsner,Ravi S. Jonnal,Donald T. Miller,Michel Paques,Hannah E. Smithson,Laura K. Young,Yuhua Zhang,Melanie C. W. Campbell,Jennifer J. Hunter,Andrew Metha,Grazyna Palczewska,Jesse Schallek,Lawrence C. Sincich +27 more
TL;DR: The editors of this feature issue have posed a series of question to scientists involved in using adaptive optics in vision science to explore how adaptive optics is being used to improve the understanding of the neurophysiology of the visual system.
Journal ArticleDOI
Wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice.
TL;DR: Wavefront sensorless adaptive optics Fourier domain optical coherence tomography (FD-OCT) for in vivo small animal retinal imaging and image quality improvements with WSAO OCT are presented.
References
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Journal ArticleDOI
Supernormal vision and high-resolution retinal imaging through adaptive optics
TL;DR: A fundus camera equipped with adaptive optics is constructed that provides unprecedented resolution, allowing the imaging of microscopic structures the size of single cells in the living human retina.
Journal ArticleDOI
Adaptive optics scanning laser ophthalmoscopy
Austin Roorda,Fernando Romero-Borja,William J. Donnelly,Hope M Queener,T.J. Hebert,Melanie C. W. Campbell +5 more
TL;DR: The first scanning laser ophthalmoscope that uses adaptive optics to measure and correct the high order aberrations of the human eye is presented, permitting axial sectioning of retinal tissue in vivo.
Journal ArticleDOI
The arrangement of the three cone classes in the living human eye
TL;DR: Adaptive optics and retinal densitometry are combined to obtain the first images of the arrangement of S, M and L cones in the living human eye, allowing the sharpest images ever taken of the living retina.
Journal ArticleDOI
Adaptive optics in microscopy
TL;DR: In this article, the sources of aberrations, their effects and their correction with adaptive optics, particularly in confocal and two-photon microscopes, are discussed. And applications of adaptive optics in the related areas of optical data storage, optical tweezers and micro/nanofabrication are also reviewed.
Journal ArticleDOI
Dynamics of the eye’s wave aberration
TL;DR: Calculations suggest that a perfect adaptive optics system with a closed-loop bandwidth of 1-2 Hz could correct these aberrations well enough to achieve diffraction-limited imaging over a dilated pupil.