Whispering Gallery Mode Carousel--a photonic mechanism for enhanced nanoparticle detection in biosensing.
TLDR
This Carousel trap, caused by attractive optical gradient forces, interfacial interactions, and the circulating momentum flux, considerably enhances the rate of transport to the sensing region, thereby overcoming limitations posed by diffusion on such small area detectors.Abstract:
Individual nanoparticles in aqueous solution are observed to be attracted to and orbit within the evanescent sensing ring of a Whispering Gallery Mode micro-sensor with only microwatts of driving power. This Carousel trap, caused by attractive optical gradient forces, interfacial interactions, and the circulating momentum flux, considerably enhances the rate of transport to the sensing region, thereby overcoming limitations posed by diffusion on such small area detectors. Resonance frequency fluctuations, caused by the radial Brownian motion of the nanoparticle, reveal the radial trapping potential and the nanoparticle size. Since the attractive forces draw particles to the highest evanescent intensity at the surface, binding steps are found to be uniform.read more
Citations
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References
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Journal ArticleDOI
Observation of a single-beam gradient force optical trap for dielectric particles
TL;DR: Optical trapping of dielectric particles by a single-beam gradient force trap was demonstrated for the first reported time, confirming the concept of negative light pressure due to the gradient force.
Journal ArticleDOI
Optical Trapping and Manipulation of Viruses and Bacteria
Arthur Ashkin,J. M. Dziedzic +1 more
TL;DR: Trapping and manipulation of single live motile bacteria and Escherichia coli bacteria were demonstrated in a high-resolution microscope at powers of a few milliwatts.
Journal ArticleDOI
Whispering-gallery-mode biosensing: label-free detection down to single molecules
Frank Vollmer,Stephen Arnold +1 more
TL;DR: The enhancement mechanisms responsible for the extreme sensitivity of the WGM biosensor are described, its current implementations and applications are reviewed, and its future possibilities are discussed.
Journal ArticleDOI
Label-Free, Single-Molecule Detection with Optical Microcavities
TL;DR: A highly specific and sensitive optical sensor based on an ultrahigh quality (Q) factor (Q > 108) whispering-gallery microcavity is reported and label-free, single-molecule detection of interleukin-2 was demonstrated in serum.
Journal ArticleDOI
Phase-matched excitation of whispering-gallery-mode resonances by a fiber taper
TL;DR: It is shown that high-Q whispering-gallery modes in fused-silica microspheres can be efficiently excited by an optical fiber taper and is believed to be the most efficient excitation of a high- Q microcavity resonance by a monomode optical fiber yet demonstrated.
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