Within-Patient Reproducibility of the Aldosterone:Renin Ratio in Primary Aldosteronism
Gian Paolo Rossi,Teresa Maria Seccia,Gaetana Palumbo,Anna Belfiore,Giampaolo Bernini,Graziella Caridi,Giovambattista Desideri,Bruno Fabris,Claudio Ferri,Gilberta Giacchetti,Claudio Letizia,Mauro Maccario,Francesca Mallamaci,Massimo Mannelli,Anna Patalano,Damiano Rizzoni,Ermanno Rossi,Achille C. Pessina,Franco Mantero +18 more
TLDR
Data from a prospective multicenter study of consecutive hypertensive patients referred to specialized centers for hypertension in Italy support the use of the plasma aldosterone concentration:renin ratio (ARR) for the screening of primary aldosteronism.Abstract:
The plasma aldosterone concentration:renin ratio (ARR) is widely used for the screening of primary aldosteronism, but its reproducibility is unknown. We, therefore, investigated the within-patient reproducibility of the ARR in a prospective multicenter study of consecutive hypertensive patients referred to specialized centers for hypertension in Italy. After the patients were carefully prepared from the pharmacological standpoint, the ARR was determined at baseline in 1136 patients and repeated after, on average, 4 weeks in the patients who had initially an ARR ≥40 and in 1 of every 4 of those with an ARR r =0.69; Pread more
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Genetics, prevalence, screening and confirmation of primary aldosteronism: a position statement and consensus of the Working Group on Endocrine Hypertension of The European Society of Hypertension.
Paolo Mulatero,Silvia Monticone,Jaap Deinum,Laurence Amar,Aleksander Prejbisz,Maria-Christina Zennaro,Felix Beuschlein,Gian Paolo Rossi,Tetsuo Nishikawa,Alberto Morganti,Teresa Maria Seccia,Yen-Hung Lin,Francesco Fallo,Jiri Widimsky +13 more
TL;DR: Experts from the European Society of Hypertension have critically reviewed the available literature and prepared a consensus document constituting two articles to summarize current knowledge on the epidemiology, diagnosis, treatment, and complications of primary aldosteronism.
Journal ArticleDOI
P-593: Drug effects on aldosterone/plasma renin activity ratio in primary aldosteronism
Paolo Mulatero,Franco Rabbia,Alberto Milan,Fulvio Morello,G. Leotta,Sara Del Colle,M. Caserta,Mirko Tredici,Franco Veglio +8 more
TL;DR: The effects of therapy with atenolol, amlodipine, doxazosin, fosinopril, and irbesartan on the aldosterone/plasma renin activity ratio (ARR) in a group of 230 patients with suspected primary aldosteronism was investigated.
Journal ArticleDOI
Primary Aldosteronism: Changing Definitions and New Concepts of Physiology and Pathophysiology Both Inside and Outside the Kidney.
TL;DR: This review summarizes current progress in understanding of the physiology of aldosterone, and towards defining the causes, causes, epidemiology, outcomes, and clinical approaches to diagnostic workup and treatment of PA.
Journal ArticleDOI
A comprehensive review of the clinical aspects of primary aldosteronism.
TL;DR: In some subgroups of patients with hypertension who are at high risk of primary aldosteronism or can benefit most from an accurate diagnosis, an aggressive diagnostic approach is necessary.
Journal ArticleDOI
Primary Aldosteronism: JACC State-of-the-Art Review
TL;DR: Moves aimed at improving the clinical use of adrenal vein sampling and at developing alternative techniques for subtyping, alongside recommendations for drug treatment, including new development in the field, and for follow-up are discussed.
References
More filters
Journal ArticleDOI
Measuring agreement in method comparison studies
J M Bland,Douglas G. Altman +1 more
TL;DR: The 95% limits of agreement, estimated by mean difference 1.96 standard deviation of the differences, provide an interval within which 95% of differences between measurements by the two methods are expected to lie.
Journal ArticleDOI
A New Biometrical Procedure for Testing the Equality of Measurements from Two Different Analytical Methods Application of linear regression procedures for method comparison studies in Clinical Chemistry, Part I
H. Passing,W. Bablok +1 more
TL;DR: A new linear regression procedure is proposed with no special assumptions regarding the distribution of the samples and the measurement errors and the result does not depend on the assignment of the methods (instruments) to X and Y.
Journal ArticleDOI
Case Detection, Diagnosis, and Treatment of Patients with Primary Aldosteronism : An Endocrine Society Clinical Practice Guideline
John W. Funder,Robert M. Carey,Carlos E. Fardella,Celso E. Gomez-Sanchez,Franco Mantero,Michael Stowasser,William F. Young,Victor M. Montori +7 more
TL;DR: The Task Force developed clinical practice guidelines for the diagnosis and treatment of patients with primary aldosteronism and recommended that patients with bilateral adrenal hyperplasia, or those unsuitable for surgery, optimally be treated medically by mineralocorticoid receptor antagonists.
Journal ArticleDOI
Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism
Paul Milliez,Xavier Girerd,Pierre-François Plouin,Jacques Blacher,Michel E. Safar,Jean-Jacques Mourad +5 more
TL;DR: Patients presenting with PA experienced more cardiovascular events than did EHT patients independent of blood pressure, and the presence of PA should be detected, not only to determine the cause of HTN, but also to prevent such complications.
Journal ArticleDOI
The STARD Statement for Reporting Studies of Diagnostic Accuracy: Explanation and Elaboration
Patrick M.M. Bossuyt,Johannes B. Reitsma,David E. Bruns,Constantine Gatsonis,Paul Glasziou,Les Irwig,David Moher,Drummond Rennie,Drummond Rennie,Henrica C.W. de Vet,Jeroen G. Lijmer +10 more
TL;DR: This explanatory document aims to facilitate the use, understanding, and dissemination of the checklist and contains a clarification of the meaning, rationale, and optimal use of each item on the checklist.
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