Worsening or improving hypoalbuminemia during continuous renal replacement therapy is predictive of patient outcome: a single-center retrospective study
Harin Rhee,Gum Sook Jang,Sungmi Kim,Wanhee Lee,Hak Su Jeon,Da Woon Kim,Byung Min Ye,Hyojin Kim,Min Jeong Kim,Seo Rin Kim,Il Young Kim,Sang Heon Song,Eun Young Seong,Dong Won Lee,Soo Bong Lee +14 more
TLDR
In this paper , the authors analyzed data that had been consecutively collected from January 2016 to December 2020 at the Third Affiliated Hospital and divided the patients into four groups based on their serum albumin levels (albumin ≥ 3.0 g/dL or < 3.Abstract:
Hypoalbuminemia at the initiation of continuous renal replacement therapy (CRRT) is a risk factor for poor patient outcomes. However, it is unknown whether the patterns of changes in serum albumin levels during CRRT can be used to predict patient outcomes.This retrospective study analyzed data that had been consecutively collected from January 2016 to December 2020 at the Third Affiliated Hospital. We included patients with acute kidney injury who received CRRT for ≥ 72 h. We divided the patients into four groups based on their serum albumin levels (albumin ≥ 3.0 g/dL or < 3.0 g/dL) at the initiation and termination of CRRT.The 793 patients in this study were categorized into the following albumin groups: persistently low, 299 patients (37.7%); increasing, 85 patients (10.4%); decreasing, 195 patients (24.6%); and persistently high, 214 patients (27.1%). In-hospital mortality rates were highest in the persistently low and decreasing groups, followed by the increasing and persistently high groups. The hazard ratio for in-hospital mortality was 0.481 (0.340-0.680) in the increasing group compared to the persistently low group; it was 1.911 (1.394-2.620) in the decreasing group compared to the persistently high group. The length of ICU stay was 3.55 days longer in the persistently low group than in the persistently high group.Serum albumin levels changed during CRRT, and monitoring of patterns of change in serum albumin levels is useful for predicting in-hospital mortality and the length of ICU stay. read more
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The association between albumin corrected anion gap and ICU mortality in acute kidney injury patients requiring continuous renal replacement therapy
TL;DR: In this paper , the relationship between albumin corrected anion gap (ACAG) and mortality in acute kidney injury (AKI) patients who received continuous renal replacement therapy (CRRT) has not been investigated in any previous studies.
Posted ContentDOI
Influence of mean arterial pressure on the decision to terminate CRRT and in-hospital mortality: A single-center prospective study
TL;DR: In this article , a prospective cohort study collected data for CRRT patients seen at the Third Affiliated Hospital from January 2016 to December 2020, and collected MAP data at the initiation of CRRT and in-hospital mortality data.
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Association between hypoalbuminemia and mortality in patients undergoing continuous renal replacement therapy: A systematic review and meta-analysis
TL;DR: In this paper , a review aimed to assess if hypoalbuminemia can predict mortality in patients undergoing continuous renal replacement therapy (CRRT), and five studies with 5254 patients were included.
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The importance of early detecting high-risk patients with acute kidney injury requiring continuous kidney replacement therapy
TL;DR: A retrospective analysis derived from multicentric electronic-based registry, the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database, with data obtained in America and China found that a high ACAG level at the initiation of CKRT was significantly associated with ICU all-cause mortality [6].
References
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Journal ArticleDOI
Atomic structure and chemistry of human serum albumin.
Xiao Min He,Daniel C. Carter +1 more
TL;DR: The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 Å and should provide insight into future pharmacokinetic and genetically engineered therapeutic applications of serumalbumin.
Journal ArticleDOI
A comparison of albumin and saline for fluid resuscitation in the intensive care unit
TL;DR: In patients in the ICU, use of either 4 percent albumin or normal saline for fluid resuscitation results in similar outcomes at 28 days, with no significant differences between the groups.
Journal ArticleDOI
The Pathogenesis of Sepsis
TL;DR: Rather than being caused by any single pathogenic mechanism, it is more likely that sepsis is related to the state of activation of the target cell, the nearby presence of other mediators, and the ability of thetarget cell to release other mediator, so the body can no longer control its own inflammatory response.
Journal ArticleDOI
ESPEN guidelines on definitions and terminology of clinical nutrition
Tommy Cederholm,Rocco Barazzoni,P. Austin,P. Austin,Peter E. Ballmer,Gianni Biolo,Stephan C. Bischoff,Charlene Compher,I. Correia,Takashi Higashiguchi,Mette Holst,Gordon L. Jensen,Ainsley Malone,Maurizio Muscaritoli,Ibolya Nyulasi,Matthias Pirlich,Elisabet Rothenberg,Karin Schindler,Stéphane M. Schneider,M.A.E. de van der Schueren,M.A.E. de van der Schueren,Cornel C. Sieber,Luzia Valentini,Jian-Chun Yu,A. Van Gossum,Pierre Singer +25 more
TL;DR: An agreement of basic nutritional terminology to be used in clinical practice, research, and the ESPEN guideline developments has been established and may help to support future global consensus efforts and updates of classification systems such as the International Classification of Disease.
Journal ArticleDOI
Diagnostic criteria for malnutrition – An ESPEN Consensus Statement
Tommy Cederholm,Ingvar Bosaeus,Rocco Barazzoni,Juergen M. Bauer,A. Van Gossum,Stanislaw Klek,Maurizio Muscaritoli,Ibolya Nyulasi,J. Ockenga,Stéphane M. Schneider,M.A.E. de van der Schueren,M.A.E. de van der Schueren,Pierre Singer +12 more
TL;DR: In individuals identified by screening as at risk of malnutrition, the diagnosis of malnutrition should be based on either a low BMI (<18.5 kg/m(2)), or on the combined finding of weight loss together with either reduced BMI (age-specific) or a low FFMI using sex-specific cut-offs.