Journal ArticleDOI
X-ray fluorescent computer tomography with synchrotron radiation
G.-F. Rust,J. Weigelt +1 more
TLDR
In this paper, the authors describe the possibility of a quantitative calculation of the distribution of a nonradioactive element within a selected cross section with nondestructive methods with the help of X-ray fluorescent tomography (XFCT) in order to increase measurement sensitivity.Abstract:
This paper describes the possibility of a quantitative calculation of the distribution of a nonradioactive element within a selected cross section with nondestructive methods with the help of X-ray fluorescent tomography (XFCT) In order to increase measurement sensitivity, the use of a lamellar collimator was avoided One of the main problems for the quantitative determination of concentration was absorption of the stimulating synchrotron ray as well as re-absorption of the emitted fluorescent light The absorption coefficients required for a consideration of the absorption processes have been determined with two absorption tomograms The algebraic reconstruction technique (ART) and the maximum likelihood method with expectation maximization (MLEM) were used for the reconstruction of the chemical element to be classified, with close consideration of the absorption phenomenon The experiments were undertaken at the bending-magnet beamline, CEMO, at the laboratory for synchrotron radiation in Hamburg, HASYLAB (45 GeV) (100 mA) The photon intensity flux was approximately 10/sup 9/ photons/mm/sup 2//s The concentration of iodine was calculated with phantoms and an untreated, dissected human thyroid gland with the help of a calibration curve The total error related to the reconstructed mean value amounts to 20% One can find at least an iodide concentration of 06 mmol/l in this experimental setupread more
Citations
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Journal ArticleDOI
Internal elemental microanalysis combining x-ray fluorescence, Compton and transmission tomography
Bruno Golosio,Alexandre Simionovici,Andrea Somogyi,Laurence Lemelle,Marina Chukalina,Antonio Brunetti +5 more
TL;DR: In this paper, an approach to the reconstruction problem is presented, which integrates the information from the three types of signals, i.e., Compton and Rayleigh scattering, for obtaining information on the internal elemental composition of the sample.
Journal ArticleDOI
Reconstructing x-ray fluorescence microtomograms
TL;DR: In this article, a self-consistently estimated attenuation of the fluorescence radiation is used to estimate the attenuation inside the sample, which allows one to reconstruct relative concentrations.
Journal ArticleDOI
Quantitative imaging of gold nanoparticle distribution in a tumor-bearing mouse using benchtop x-ray fluorescence computed tomography
TL;DR: This investigation identifies a clear path toward in vivo molecular imaging using benchtop XFCT techniques in conjunction with GNPs and other metallic probes, up to two orders of magnitude better than conventional x-ray CT.
Journal ArticleDOI
Investigation of X-ray Fluorescence Computed Tomography (XFCT) and K-Edge Imaging
TL;DR: A comprehensive Monte Carlo study of X-ray fluorescence computed tomography (XFCT) and K-edge imaging system, including the system design, the influence of various imaging components, the sensitivity and resolution under various conditions, is provided.
Journal ArticleDOI
High-resolution X-ray fluorescence microtomography of homogeneous samples
Alexandre Simionovici,Marina Chukalina,Christian G. Schroer,Michael Drakopoulos,A. A. Snigirev,Irina Snigireva,Bruno Lengeler,Koen Janssens,F. C. Adams +8 more
TL;DR: In this article, the first experimental results of fluorescence microtomography with 6 /spl mu/m resolution obtained at ESRF, Grenoble, France, are described.
References
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Book
Principles of Computerized Tomographic Imaging
TL;DR: Properties of Computerized Tomographic Imaging provides a tutorial overview of topics in tomographic imaging covering mathematical principles and theory and how to apply the theory to problems in medical imaging and other fields.
Journal ArticleDOI
Maximum Likelihood Reconstruction for Emission Tomography
L. A. Shepp,Y. Vardi +1 more
TL;DR: In this paper, the authors proposed a more accurate general mathematical model for ET where an unknown emission density generates, and is to be reconstructed from, the number of counts n*(d) in each of D detector units d. Within the model, they gave an algorithm for determining an estimate? of? which maximizes the probability p(n*|?) of observing the actual detector count data n* over all possible densities?.
Journal Article
EM reconstruction algorithms for emission and transmission tomography.
Kenneth Lange,Richard E. Carson +1 more
TL;DR: The general principles behind all EM algorithms are discussed and in detail the specific algorithms for emission and transmission tomography are derived and the specification of necessary physical features such as source and detector geometries are discussed.
Journal ArticleDOI
Representation of a Function by Its Line Integrals, with Some Radiological Applications
TL;DR: In this paper, a method for finding a real function in a finite region of a plane given its line integrals along all straight lines intersecting the region was given, and the solution found is applicable to three problems of interest for precise radiology and radiotherapy: (1) the determination of a variable x-ray absorption coefficient in two dimensions, (2) the distribution of positron annihilations when there is an inhomogeneous distribution of the positron emitter in matter, and (3) a variable density of matter with constant chemical composition, using the energy loss
Journal ArticleDOI
Iterative methods for the three-dimensional reconstruction of an object from projections
TL;DR: It is shown that in general ART produces erroneous reconstructions, and an alternative iterative method is proposed which will give correct reconstructions under certain conditions.
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R. Cesareo,Sérgio Mascarenhas +1 more