Journal ArticleDOI
Zinc Metabolism and Metallothioneins.
TLDR
Information is given on metallothioneins, which have critical importance in the metabolism and molecular pathways of zinc, which points to the critical part it plays in oxidative stress.Abstract:
Among the trace elements, zinc is one of the most used elements in biological systems. Zinc is found in the structure of more than 2700 enzymes, including hydrolases, transferases, oxyreductases, ligases, isomerases, and lyases. Not surprisingly, it is present in almost all body cells. Preserving the stability and integrity of biological membranes and ion channels, zinc is also an intracellular regulator and provides structural support to proteins during molecular interactions. It acts as a structural element in nucleic acids or other gene-regulating proteins. Metallothioneins, the low molecular weight protein family rich in cysteine groups, are involved significantly in numerous physiological and pathological processes including particularly oxidative stress. A critical role of metallothioneins (MT) is to bind zinc with high affinity and to serve as an intracellular zinc reservoir. By releasing free intracellular zinc when needed, MTs mediate the unique physiological roles of zinc. MT expression is induced by zinc elevation, and thus, zinc homeostasis is maintained. That MT mediates the effects of zinc, besides having strong radical scavenging effects, points to the critical part it plays in oxidative stress. The present review aims to give information on metallothioneins, which have critical importance in the metabolism and molecular pathways of zinc.read more
Citations
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Ganong's review of medical physiology
Cellular,Michael Weitz +1 more
TL;DR: Ganong's review of medical physiology, Ganong's Review of Medical physiology , کتابخانه دیجیتال جندی اهواز is published.
Journal ArticleDOI
Recent aspects of the effects of zinc on human health.
Christos T. Chasapis,Christos T. Chasapis,Panagoula-Stamatina A. Ntoupa,Chara Spiliopoulou,Maria Stefanidou +4 more
TL;DR: This review gives a thorough insight into the most recent evidence on the association between Zn biochemistry and human pathologies, epigenetic processes, gut microbial composition, drug targets and nanomedicine.
Journal ArticleDOI
Association Between Low Zinc Levels and Severity of Acute Respiratory Distress Syndrome by New Coronavirus SARS-CoV-2.
Thiago José Martins Gonçalves,Sandra Elisa Adami Batista Gonçalves,Andreia Guarnieri,Rodrigo Cristovão Risegato,Maysa Penteado Guimarães,Daniella Cabral de Freitas,Alvaro Razuk-Filho,Pedro Batista Benedito Junior,Eduardo Fagundes Parrillo +8 more
TL;DR: In this article, the prevalence of low zinc levels among critically ill patients infected by SARS-CoV-2 in the intensive care unit (ICU) who required invasive mechanical ventilation, as well as its association with severity of acute respiratory distress syndrome (ARDS).
Journal ArticleDOI
Role of Zinc Supplementation on Ischemia/Reperfusion Injury in Various Organs.
TL;DR: It is suggested that Zn can be administered before elective surgeries for prevention of side effects of I/R injury and increases phosphatidylinositol 3-kinase (PI3K)/Akt and glycogen synthase kinase-3 β (GSK-3β) phosphorylation and preserves protein kinase C isoforms.
References
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Journal ArticleDOI
Zinc finger proteins: new insights into structural and functional diversity.
TL;DR: Structures have recently been reported for many new zinc finger domains with novel topologies, providing important insights into structure/function relationships and into mechanisms of DNA binding and to a better understanding of their broader functions in transcriptional regulation.
Journal ArticleDOI
The inhibitors of apoptosis (IAPs) and their emerging role in cancer.
Eric C. LaCasse,Stephen Baird,Stephen Baird,Robert G. Korneluk,Robert G. Korneluk,Alex MacKenzie,Alex MacKenzie +6 more
TL;DR: A picture consistent with an IAP role in tumour progression rather than tumour initiation is emerging making the IAPs an attractive therapeutic target.
Journal ArticleDOI
Zinc in human health: effect of zinc on immune cells.
TL;DR: The studies in the cell culture models showed that the activation of many zinc-dependent enzymes and transcription factors were adversely affected due to zinc deficiency, and zinc supplementation decreased oxidative stress markers and generation of inflammatory cytokines.
Journal ArticleDOI
Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite
TL;DR: Evidence is presented of the first evidence that peroxynitrite (ONOO(-)) releases zinc from the zinc-thiolate cluster of endothelial NOS (eNOS) and presumably forms disulfide bonds between the monomers, providing a novel mechanism for modulation of the enzyme function in disease.
Journal ArticleDOI
Functions of zinc in signaling, proliferation and differentiation of mammalian cells.
Detmar Beyersmann,Hajo Haase +1 more
TL;DR: New hypotheses regarding regulatory functions of zinc ions in cellular signaling pathways are proposed as a conclusion of observations on zinc homeostasis in eukaryotic cells.
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