Can apoptosis be stopped?
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Open access•Journal Article | ABL therefore can specifically suppress apoptosis. |
128 Citations | Moreover, NO-dependent apoptosis can be blocked in most cases through the use of permeability transition or caspase inhibitors. |
| We have identified “windows of opportunity” at which time apoptosis can be aborted and cells can be reversed from the death pathway. | |
12 Citations | After this careful reflection I am convinced that apoptosis is merely the complex machinery of cellular decay after energy generation has irreversibly stopped. |
| Our data showed that in particular micronucleated cells, originating from chromosome loss can be eliminated by apoptosis. | |
37 Citations | We showed that apoptosis precedes necrosis in humans, but the detection of apoptosis cannot be used as a diagnostic tool, since it can also be triggered by nonischemic events. |
98 Citations | There is some evidence that certain symptoms of "apoptosis" such as endonuclease activation can be spuriously induced without engaging a genetic cascade, however, presumably true apoptosis and programmed cell death must be genetically mediated. |
102 Citations | Moreover, apoptosis of tumor cells can also be achieved by targeting the inhibitor of apoptosis proteins, IAPs, in addition to the classical antiproliferative approach. |
170 Citations | It is suggested that apoptosis can be specifically regulated pharmacologically and could be exploited to develop new drug therapies. |
316 Citations | These non-apoptotic cell death modalities can be either triggered independently of apoptosis or are engaged should apoptosis fail to execute. |
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